Evidence map›Paper›PMID 40607298›Full record

ArticleAnnals of gastroenterological surgery2025

Clinical role of intraperitoneal chemotherapy in patients with pancreatic ductal adenocarcinoma concomitant with occult peritoneal dissemination: A multicenter retrospective study.

Tomohisa Yamamoto, Toshio Shimokawa, Masamichi Hayashi, Masamichi Mizuma, Katsuhisa Hirano, Atsushi Oba, Toshimichi Asano, Hideyo Miyato, Makoto Yoshida, Ippei Matsumoto and 24 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of gastroenterological surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Tomohisa YamamotoDepartment of Pancreatobiliary Surgery Kansai Medical University Osaka Japan.ORCID https://orcid.org/0000-0002-7951-7429
Toshio ShimokawaClinical Study Support Center, Wakayama Medical University School of Medicine Wakayama Japan.
Masamichi HayashiDepartment of Gastroenterological Surgery Nagoya University Graduate School of Medicine Nagoya Japan.
Masamichi MizumaDepartment of Surgery Tohoku University Graduate School of Medicine Sendai Japan.
Katsuhisa HiranoDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly University of Toyama Toyama Japan.
Atsushi ObaDivision of Hepatobiliary and Pancreatic Surgery Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan.ORCID https://orcid.org/0000-0002-7315-0830
Toshimichi AsanoDepartment of Gastroenterological Surgery II, Faculty of Medicine Hokkaido University Sapporo Japan.
Hideyo MiyatoDepartment of Gastrointestinal Surgery Jichi Medical University Shimotsuke Japan.
Makoto YoshidaDepartment of Medical Oncology Sapporo Medical University School of Medicine Sapporo Japan.
Ippei MatsumotoDepartment of Surgery Kindai University Faculty of Medicine Osaka Japan.ORCID https://orcid.org/0000-0003-3965-3693
Yasunari KawabataDepartment of Digestive and General Surgery Shimane University Faculty of Medicine Izumo Japan.
Katsunori SakamotoDepartment of Hepato-Biliary-Pancreatic and Breast Surgery Ehime University Graduate School of Medicine Ehime Japan.
Fuyuhiko MotoiDepartment of Surgery Yamagata University Graduate School of Medical Science Yamagata Japan.ORCID https://orcid.org/0000-0001-7601-8395
Shigeto IshiiDepartment of Gastroenterology, Graduate School of Medicine Juntendo University Tokyo Japan.
Yuki HommaDepartment of Gastroenterological Surgery Yokohama City University Graduate School of Medicine Yokohama Japan.
Hiromitsu MaehiraDepartment of Surgery Shiga University of Medical Science Otsu Japan.
Yutaro MatsunagaDepartment of Surgery, Institute of Gastroenterology Tokyo Women's Medical University Tokyo Japan.
Tetsuya IkemotoDepartment of Surgery Tokushima University Tokushima Japan.ORCID https://orcid.org/0000-0001-9800-1359
Masafumi NakamuraDepartment of Surgery and Oncology, Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Yuko MatakiDepartment of Digestive Surgery, Graduate School of Medicine Kagoshima University Kagoshima Japan.
Tsuyoshi NotakeDivision of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation, and Pediatric Surgery, Department of Surgery Shinshu University School of Medicine Nagano Japan.ORCID https://orcid.org/0000-0002-2277-5347
Keiichi AkahoshiDepartment of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine Tokyo Medical and Dental University Tokyo Japan.
Hideki TakamiDepartment of Gastroenterological Surgery Nagoya University Graduate School of Medicine Nagoya Japan.
So YamakiDepartment of Pancreatobiliary Surgery Kansai Medical University Osaka Japan.
Daisuke HashimotoDepartment of Pancreatobiliary Surgery Kansai Medical University Osaka Japan.ORCID https://orcid.org/0000-0002-7880-889X
Yasutoshi KimuraDepartment of Surgery, Surgical Oncology and Science Sapporo Medical University School of Medicine Sapporo Japan.ORCID https://orcid.org/0000-0002-7790-9250
Satoshi HiranoDepartment of Gastroenterological Surgery II, Faculty of Medicine Hokkaido University Sapporo Japan.
Yosuke InoueDivision of Hepatobiliary and Pancreatic Surgery Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan.
Tsutomu FujiiDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly University of Toyama Toyama Japan.ORCID https://orcid.org/0000-0003-0625-1911
Michiaki UnnoDepartment of Surgery Tohoku University Graduate School of Medicine Sendai Japan.
Yasuhiro KoderaDepartment of Gastroenterological Surgery Nagoya University Graduate School of Medicine Nagoya Japan.ORCID https://orcid.org/0000-0002-6173-7474
Joji KitayamaDepartment of Gastrointestinal Surgery Jichi Medical University Shimotsuke Japan.ORCID https://orcid.org/0000-0002-5708-7130
Sohei SatoiDepartment of Pancreatobiliary Surgery Kansai Medical University Osaka Japan.ORCID https://orcid.org/0000-0001-6527-5409
Study Group of Pancreatic Ductal Adenocarcinoma with Peritoneal Dissemination

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The effectiveness of intraperitoneal chemotherapy using paclitaxel (i.p.-PTX) in pancreatic ductal adenocarcinoma (PDAC) patients with peritoneal dissemination remains elusive. The aim of this study is to investigate the clinical outcome of patients treated with i.p.-PTX combined with systemic chemotherapy compared with current standard chemotherapy including gemcitabine plus nab-paclitaxel and FOLFIRINOX. Methods: Data of patients with peritoneal dissemination was retrospectively collected and analyzed (i.p.-PTX, Results: No significant differences were noted in overall survival (14.9 vs. 15.5 months, Conclusion: The i.p. PTX regimen prolonged PFS but not overall survival, and subgroup analysis suggested the possibility of survival benefit in patients with occult peritoneal dissemination whose primary tumor was classified as resectable/borderline resectable disease.

Indexed as

intraperitoneal chemotherapyperitoneal dissemination

Identifiers

PMID40607298
PMCPMC12211105

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.