ArticleAnnals of gastroenterological surgery2025
Late anastomotic complication after laparoscopic surgery for clinical stage I low rectal cancers located within 5 cm of the anal verge: Sub-analysis of the ultimate trial.
Article in Annals of gastroenterological surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- An ultra-minimally invasive attempt: endoscopic hand-suturing for delayed anastomotic fistula after low rectal cancer surgery.Endoscopy · 2026Article
- Indocyanine green fluorescence angiography in laparoscopic sigmoid and rectal cancer surgery: no reduction in anastomotic leakage but a lower incidence of anastomotic strictures. A prospective single-center study.Frontiers in surgery · 2026Article
- Laparoscopic Rectopexy for Neorectal Prolapse after Robot-Assisted Intersphincteric Resection for Low Rectal Cancer: A Case Report.Surgical case reports · 2026Article
- Late anastomotic complication after laparoscopic surgery for clinical stage I low rectal cancers located within 5 cm of the anal verge: Sub-analysis of the ultimate trial.Annals of gastroenterological surgery · 2025Article
- My Encounters and Progress with Minimally Invasive Surgery.Juntendo medical journal · 2025Article
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Authors and funding
30 authors.
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Abstract
Background: Although extensive research has been conducted on early anastomotic leakage (AL) after sphincter-sparing surgery, the status of late anastomotic complications (post-30 days) has received limited attention. These late complications significantly affect a patient's quality of life and often lead to permanent stoma creation. Methods: This study conducted a sub-analysis of a phase II trial assessing the outcomes of laparoscopic surgery for cStage I lower rectal adenocarcinoma (the ultimate trial). This study included 278 patients who underwent intestinal anastomosis and investigated the frequency, timing, and risk factors of late anastomotic complications (stenosis, fistula, and intestinal prolapse). Results: Anastomotic stenosis occurred in 27 patients (9.7%), and the median time of occurrence was 274 days (range, 70-1226 days). Only early AL ( Conclusion: Anastomotic stenosis and late fistula formation frequently emerge as secondary consequences of early AL and represent significant complications linked to permanent stoma creation, often proving resistant to treatment. Intestinal prolapse is a characteristic anastomotic complication of ISR that can be caused by excessive intestinal mobilization.
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