ArticleThe Pan African medical journal2025
Dolutegravir combined anti-retroviral agents as second-line drugs and virologic suppression of adults with HIV in Federal Teaching Hospital, Ido Ekiti - case series.
Article in The Pan African medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The transition to dolutegravir (DTG)-combined anti-retroviral therapy (ART) as a preferred option in both first- and second-line for all populations was adopted by the World Health Organization (WHO) due to encouraging safety data for women and adolescent girls during the peri-conception period. This case series aimed at determining the viral suppression of adults with HIV on Dolutegravir combined anti-retroviral agents as second-line drugs. Four clients' viral suppression were observed from ART initiation to switching to second line and later transiting to the DTG-combined regimen and the findings was that clients A and B, who were transitioned to the DTG-combined regimen had superior viral suppression by three months when compared to clients C and D who were switched to second line. The case series supports the WHO recommendation that the DTG-based regimen is the preferred first- and second-line switch ART regimen in HIV management, in achieving faster viral load suppression than any other regimen.
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