ArticleFrontiers in endocrinology2025
The risk of hyperuricemia assessed by estimated glucose disposal rate.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Insulin resistance evaluated by estimated glucose disposal rate and its association with cardiometabolic risk factors among adolescents in Northeast China.Frontiers in nutrition · 2026Article
- Estimated small dense low-density lipoprotein cholesterol and hyperuricemia in diabetic patients.Frontiers in endocrinology · 2026Article
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Authors and funding
4 authors.
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Abstract
Purpose: The estimated glucose disposal rate (eGDR) is a simple and noninvasive clinical measure used to assess insulin resistance (IR), yet its potential utility as a marker for hyperuricemia risk had not been systematically evaluated. This study aimed to investigate the relationship between eGDR and hyperuricemia risk among American adults. Methods: Data for this cross-sectional study were obtained from the 2007-2018 National Health and Nutrition Examination Survey (NHANES). Hyperuricemia was identified as a serum urate (SU) concentration of ≥7 mg/dL in males and ≥6 mg/dL in females. The relationship between eGDR and hyperuricemia risk was assessed using multivariate logistic regression and restricted cubic spline (RCS) methods, with additional subgroup and interaction analyses performed. Results: With increasing eGDR values, the prevalence of hyperuricemia decreased significantly (29.93% vs. 19.11% vs. 13.20% vs. 5.03%, Conclusions: The eGDR is inversely associated with hyperuricemia and appears to be a promising epidemiological tool for evaluating the impact of IR on the risk of hyperuricemia.
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