Evidence map›Paper›PMID 40607230›Full record

ArticleFrontiers in endocrinology2025

Reprogramming energy homeostasis in children with overweight through cognitive training and social interaction. A study protocol to estimate leptin sensitivity.

Valentina Russo, Deny Menghini, Marco Mainardi, Danilo Fintini, Alessia Aureli, Nicoletta Gianni, Lucilla Ravà, Maria Alessia Rea, Gabriele Scozia, Chiara Spiezia and 6 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06931730 (Reprogramming Energy Homeostasis in Overweight Children and Adults Trough Exercise, Cognitive Training and Social Interaction), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06931730 narecruitingnot on this map

Reprogramming Energy Homeostasis in Overweight Children and Adults Trough Exercise, Cognitive Training and Social Interaction

TypeinterventionalSponsorBambino Gesù Hospital and Research InstituteRan2024 to 2025Enrolled240ConditionsObesity and Overweight, Leptin Resistance, Childhood ObesityArmsNutritional Intervention, Physical Activity training, Cognitive training, Social Training
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Valentina RussoChild and Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Deny MenghiniChild and Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Marco MainardiDepartment of Biomedical Sciences, University of Padua, Padua, Italy.
Danilo FintiniEndocrinology and Diabetes Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Alessia AureliEndocrinology and Diabetes Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Nicoletta GianniResearch Unit for Preventive and Predictive Medicine, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Lucilla RavàClinical Epidemiology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Maria Alessia ReaResearch Unit for Preventive and Predictive Medicine, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Gabriele ScoziaChild and Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Chiara SpieziaResearch Unit of Food Science and Human Nutrition, Department of Science and Technology for Sustainable Development and One Health, Campus Bio-Medico University, Rome, Italy.
Gaia ScabiaInstitute of Clinical Physiology, National Research Council, Pisa, Italy.
Giulia FuriniInstitute of Clinical Physiology, National Research Council, Pisa, Italy.
Stefano VicariChild and Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Stefano CianfaraniEndocrinology and Diabetes Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Margherita MaffeiInstitute of Clinical Physiology, National Research Council, Pisa, Italy.
Melania MancoResearch Unit for Preventive and Predictive Medicine, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leptin is a hormone secreted by adipocytes in proportion to the size of adipose tissue. By acting on its receptor, LepRb, primarily expressed in the hypothalamus, leptin promotes a negative energy balance by strongly suppressing appetite and stimulating energy expenditure. The majority of patients with obesity exhibit elevated leptin production, indicating that leptin becomes ineffective in regulating energy balance in this context. In the growing child, leptin modulates synaptic plasticity and thus leptin resistance may exert a key role in neurodevelopment. So far, studies in humans have investigated leptin secretion but not leptin resistance. We designed a research protocol (RESILIENT project) to study leptin sensitivity Clinical trial registration: https://clinicaltrials.gov/study/, identifier NCT06931730.

Indexed as

Energy MetabolismHomeostasisLeptinOverweightPediatric ObesityChildCognitionCognitive TrainingFemaleHumansMaleRandomized Controlled Trials as TopicLeptinchildhood obesitychildhood overweightcognitive trainingenvironmental enrichmentleptinleptin sensitivitylifestyle modificationsocial training

Identifiers

PMID40607230
PMCPMC12213431

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.