ArticleFrontiers in endocrinology2025
Elevated mean arterial pressure and risk of impaired fasting glucose: a multicenter cohort study revealing age and sex interactions.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Association between estimated pulse wave velocity and impaired fasting glucose: a multicenter retrospective cohort study in China.Frontiers in endocrinology · 2026Article
- Multiple blood pressure parameters and risk of incident diabetes in adults with elevated blood pressure: a cohort study with non-linear analyses.Frontiers in endocrinology · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Evidence connecting mean arterial pressure (MAP) with impaired fasting glucose (IFG) was currently insufficient. The purpose of our research was to investigate how age and sex individually affect the relationship between MAP and the onset of IFG. Methods: Our study was a retrospective cohort analysis involving 184,291 participants from a multicenter health examination in China. The relationship between MAP and the onset of IFG was evaluated using Cox regression analysis. To further investigate the relationship, smooth curve fitting was applied to evaluate the dose-response association, while threshold effect analysis was performed to identify potential inflection points in MAP. Additionally, interaction effect analysis was conducted to examine whether age and sex modified the association between MAP and IFG risk. Results: The overall incidence of IFG was 11.28%. After multivariate adjustment, a significant positive association was observed between MAP and IFG risk (Hazard Ratio: 1.14, 95% Confidence Interval: 1.12-1.16, Conclusions: Our study revealed new insights into how MAP and IFG development were related, highlighting the influence of age and sex. These results stressed the need to consider MAP, age, and sex in IFG prevention, especially in high-MAP groups. Further investigation into the biological and behavioral mechanisms underlying these age- and sex-dependent relationships is warranted to inform personalized approaches for diabetes prevention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.