ReviewFrontiers in endocrinology2025
Inflammation of the male reproductive system: clinical aspects and mechanisms.
Review in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Analysis of research hotspots and trends in epididymitis from 2014 to 2025: a visual analysis based on bibliometrics and scientific graphs from multiple databases.Frontiers in medicine · 2026Pooled it
- Microbiome and aging: Trajectories of microbiome age across human ecosystems and their systemic effects.iMeta · 2026Review
- Microbiota contributes to regulates the external genitalia development through gut-testis axis in male geese.Poultry science · 2026Article
- Quality, content structure, and reliability of prostatitis-related information on short-video platforms: a cross-platform analysis of TikTok and Bilibili.BMC urology · 2026Article
- Environmental influences on seminal plasma: Molecular and functional insights.The Journal of reproduction and development · 2026Review
- Research progress on the multidimensional mechanisms underlying impaired spermatogenesis induced by pathological microenvironment remodeling in chronic prostatitis.Frontiers in immunology · 2026Review
- Exploratory Review on Male Fertility Potential of Acetyl-Eugenol: Mechanistic Insights, Experimental Evidence, and Therapeutic Prospects.Journal of experimental pharmacology · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The male reproductive system (MRS) is composed of multiple highly organized components that are relatively separated and adopt special histological and immunological microenvironments. The inflammatory conditions are most frequent pathological states of the MRS. Retrograde microbial infections are pivotal etiological factors contributing to acute inflammation in the MRS. However, the majority of inflammatory conditions in the MRS can be caused by non-infectious factors and manifest chronic inflammation, which may significantly affect quality of life and fertility. The mechanisms underlying the non-infectious inflammation in the MRS remain largely elusive. Therefore the diagnosis and treatment of the non-infectious inflammation in the MRS are confusing. Recent studies demonstrated that immunogenic spermatozoa could be potential triggers of the non-infectious inflammation in the MRS. This review article outlines current status of the diagnosis and the treatment of inflammation and underlying mechanisms in the MRS. We also highlight the prioritized issues for future studies.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.