Evidence map›Paper›PMID 40607158›Full record

ArticleDiabetology international2025

Renal function trajectories of Japanese adults with diabetic kidney disease on different diet therapies including energy-restricted and low-carbohydrate diets: a retrospective cohort study.

Tomomi Shirai, Sakiko Inaba, Miyu Maemura, Maki Saho, Miyu Sato, Mariko Sanada, Yoko Tsukamoto, Gaku Inoue, Taichi Nagahisa, Shinichi Tanaka and 5 more

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Article in Diabetology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Tomomi ShiraiDiabetes Center, Kitasato University Kitasato Institute Hospital, 5-9-1 Shirokane, Minato-Ku, Tokyo, 108-0072 Japan.ORCID 0000-0002-9098-0035
Sakiko InabaDepartment of Food and Nutritional Science, Graduate School of Applied Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-Ku, Tokyo, 156-8502 Japan.
Miyu MaemuraFaculty of Land and Food System, The University of British Columbia, 2329 West Mall, Vancouver, BC V6T 1Z4 Canada.
Maki SahoDiabetes Center, Kitasato University Kitasato Institute Hospital, 5-9-1 Shirokane, Minato-Ku, Tokyo, 108-0072 Japan.
Miyu SatoDiabetes Center, Kitasato University Kitasato Institute Hospital, 5-9-1 Shirokane, Minato-Ku, Tokyo, 108-0072 Japan.
Mariko SanadaDiabetes Center, Kitasato University Kitasato Institute Hospital, 5-9-1 Shirokane, Minato-Ku, Tokyo, 108-0072 Japan.
Yoko TsukamotoDiabetes Center, Kitasato University Kitasato Institute Hospital, 5-9-1 Shirokane, Minato-Ku, Tokyo, 108-0072 Japan.
Gaku InoueDiabetes Center, Kitasato University Kitasato Institute Hospital, 5-9-1 Shirokane, Minato-Ku, Tokyo, 108-0072 Japan.
Taichi NagahisaDiabetes Center, Kitasato University Kitasato Institute Hospital, 5-9-1 Shirokane, Minato-Ku, Tokyo, 108-0072 Japan.
Shinichi TanakaDepartment of Diabetes and Endocrinology, Tokyo Saiseikai Central Hospital, 1-4-17 Mita, Minato-Ku, Tokyo 108-0073 Japan.
Hajime TanakaDepartment of Diabetes and Endocrinology, Tokyo Saiseikai Central Hospital, 1-4-17 Mita, Minato-Ku, Tokyo 108-0073 Japan.
Hideaki KurataDepartment of Diabetes and Endocrinology, Tokyo Saiseikai Central Hospital, 1-4-17 Mita, Minato-Ku, Tokyo 108-0073 Japan.
Takeshi KatsukiDepartment of Diabetes and Endocrinology, Tokyo Saiseikai Central Hospital, 1-4-17 Mita, Minato-Ku, Tokyo 108-0073 Japan.
Toshihide KawaiDepartment of Diabetes and Endocrinology, Tokyo Saiseikai Central Hospital, 1-4-17 Mita, Minato-Ku, Tokyo 108-0073 Japan.
Satoru YamadaDiabetes Center, Kitasato University Kitasato Institute Hospital, 5-9-1 Shirokane, Minato-Ku, Tokyo, 108-0072 Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Recently, the Japan Diabetes Society changed its nutrition recommendations and now recognizes a low-carbohydrate diet as an effective dietary approach. There has been controversy regarding low-carbohydrate diets in relation to renal function. That is, high protein intake may lead to renal damage through hyperfiltration. Global nutritional therapy for diabetic kidney disease (DKD) recommends a protein intake of 0.8 g/kg body weight (BW)/day. In Japan, the recommended protein intake is precisely determined based on the chronic kidney disease stage. However, evidence supporting the positive health impact of such protein restriction is scarce. Therefore, we aimed to investigate the effect of a low-carbohydrate diet without protein restriction on the estimated glomerular filtration rate (eGFR) decline rate. Methods: Clinical data of patients with DKD in Tokyo Saiseikai Central Hospital and Kitasato Institute Hospital in Japan were retrospectively analyzed between February 2019 and December 2023. Sixty-eight participants were classified into two groups based on their diet: the energy-restricted and low-carbohydrate groups. Results: The protein intake of the low-carbohydrate group was significantly higher than that of the energy-restricted group (1.2 ± 0.4 and 1.0 ± 0.2 g/kg BW/day, respectively). No significant differences were observed in the baseline, endpoint, or slope of eGFR between the two groups. Conclusions: This study suggests that among Japanese adults with DKD, the protein intake difference between energy-restricted and low-carbohydrate diets does not form any gap in eGFR decline rates. Supplementary Information: The online version contains supplementary material available at 10.1007/s13340-025-00808-y.

Indexed as

CKDDiabetes mellitusDKDeGFRLow-carbohydrate dietNutritional therapy

Identifiers

PMID40607158
PMCPMC12209081

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.