Evidence map›Paper›PMID 40607156›Full record

ArticleDiabetology international2025

Metformin induces diarrhea in mice under over-eating conditions.

Kotomi Chikama, Hiroshi Takemroi, Momoka Mizoguchi, Saho Furukawa, Koutarou Terada, Masafumi Ito, Hirotsugu Hirano, Takanori Miura, Koichi Doi, Megumi Horiya and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kotomi ChikamaDepartment of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University, Yanagido 1-1, Gifu, 501-1193 Japan.
Hiroshi TakemroiDepartment of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University, Yanagido 1-1, Gifu, 501-1193 Japan.ORCID 0000-0002-1815-2964
Momoka MizoguchiDepartment of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University, Yanagido 1-1, Gifu, 501-1193 Japan.
Saho FurukawaDepartment of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University, Yanagido 1-1, Gifu, 501-1193 Japan.
Koutarou TeradaDepartment of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University, Yanagido 1-1, Gifu, 501-1193 Japan.
Masafumi ItoTaiko Pharmaceutical Co., Ltd., Honnmachi 1-4-1, Nishiku, Osaka 550-0005 Japan.
Hirotsugu HiranoTaiko Pharmaceutical Co., Ltd., Honnmachi 1-4-1, Nishiku, Osaka 550-0005 Japan.
Takanori MiuraTaiko Pharmaceutical Co., Ltd., Honnmachi 1-4-1, Nishiku, Osaka 550-0005 Japan.
Koichi DoiTaiko Pharmaceutical Co., Ltd., Honnmachi 1-4-1, Nishiku, Osaka 550-0005 Japan.
Megumi HoriyaDepartment of Diabetes, Endocrinology and Metabolism/Department of Rheumatology and Clinical Immunology, Yanagido 1-1, Gifu, 501-1194 Japan.
Takehiro KatoDepartment of Diabetes, Endocrinology and Metabolism/Department of Rheumatology and Clinical Immunology, Yanagido 1-1, Gifu, 501-1194 Japan.
Daisuke YabeDepartment of Diabetes, Endocrinology and Metabolism/Department of Rheumatology and Clinical Immunology, Yanagido 1-1, Gifu, 501-1194 Japan.
Takashi ShibataTaiko Pharmaceutical Co., Ltd., Honnmachi 1-4-1, Nishiku, Osaka 550-0005 Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metformin, an oral medication for type 2 diabetes, causes severe diarrhea in approximately 5% of individuals with diabetes in Japan, leading them to discontinue treatment despite the drug efficacy, safety, and low economic burden. Given the absence of animal models for diarrhea, we previously proposed a mouse model for metformin-induced diarrhea using diabetic obese Supplementary Information: The online version contains supplementary material available at 10.1007/s13340-025-00822-0.

Indexed as

cAMPCelluloseDiarrheaGLP-1Metformin

Identifiers

PMID40607156
PMCPMC12209130

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.