Evidence map›Paper›PMID 40607154›Full record

ArticleDiabetology international2025

CIDEC is most closely associated with fat storage in human adipose tissue among CIDE family isoforms in severely obese subjects: a cross-sectional study.

Yasuyuki Iwahashi, Seiji Nishikage, Yusei Hosokawa, Tomoko Yamada, Yasushi Nakagawa, Yushi Hirota, Kazuhiko Sakaguchi, Yuki Nishimoto, Shinsuke Nakajima, Seiichi Kitahama and 4 more

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Article in Diabetology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yasuyuki IwahashiDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017 Japan.
Seiji NishikageDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017 Japan.
Yusei HosokawaDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017 Japan.
Tomoko YamadaDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017 Japan.
Yasushi NakagawaDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017 Japan.
Yushi HirotaDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017 Japan.
Kazuhiko SakaguchiDivision of General Internal Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017 Japan.
Yuki NishimotoDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017 Japan.
Shinsuke NakajimaDepartment of Diabetes and Endocrinology, Center for Obesity, Diabetes, and Endocrinology, Chibune General Hospital, 3-2-39 Fuku-Machi, Nishiyodogawa-Ku, Osaka, 555-0034 Japan.
Seiichi KitahamaDepartment of Metabolic and Bariatric Surgery, Center for Obesity, Diabetes, and Endocrinology, Chibune General Hospital, 3-2-39 Fuku-Machi, Nishiyodogawa-Ku, Osaka, 555-0034 Japan.
Yasuyoshi YamamotoDepartment of General Surgery, Chibune General Hospital, 3-2-39 Fuku-Machi, Nishiyodogawa-Ku, Osaka, 555-0034 Japan.
Tomoichiro MukaiDepartment of General Surgery, Chibune General Hospital, 3-2-39 Fuku-Machi, Nishiyodogawa-Ku, Osaka, 555-0034 Japan.
Wataru OgawaDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017 Japan.
Yoshikazu TamoriDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017 Japan.ORCID 0000-0003-3653-5683

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cell death-inducing DFF45-like effector (CIDE) family comprises CIDEA, CIDEB, and CIDEC (fat-specific protein of 27 kDa), all of which are lipid droplet-associated proteins and contribute to fat storage and energy homeostasis. However, the relative impacts of these isoforms on fat storage in adipose tissue and obesity in humans have been unclear. We here examined the expression of CIDE family genes in visceral adipose tissue (VAT) of obese individuals who underwent laparoscopic sleeve gastrectomy and explored its relation to adiposity-related parameters. RNA-sequencing analysis revealed that Supplementary Information: The online version contains supplementary material available at 10.1007/s13340-025-00806-0.

Indexed as

Adipose tissueCIDECFat massObesity

Identifiers

PMID40607154
PMCPMC12209148

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.