ArticleBioactive materials2025
Comparison of 5 BMPs for their chondrogenic potentials and microfracture-mediated cartilage repair using heparin/PEAD coacervate sustained release polymer.
Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Human BMP4 mRNA Encapsulated in Lipid Nanoparticle for Bone and Articular Cartilage Repair in Aged Mice.Journal of functional biomaterials · 2026Article
- Protein-Encoding Chemically Modified mRNAs for Musculoskeletal Tissue Regeneration and Repair.Journal of functional biomaterials · 2026Review
- Heparin-Based Biomaterials for Sustained Release of Growth Factors for Bone Tissue Engineering and Regeneration.Journal of functional biomaterials · 2026Review
- Adipose Tissue Engineering Biomaterials: Smart Scaffolds, Vascularization, and Clinical Frontiers.Biomolecules · 2026Review
- Canonical and emerging regulatory mechanisms of tissue remodeling: shared principles across organs and therapeutic opportunities.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cartilage defect repair and osteoarthritis treatments remain clinical challenges. Microfracture is a commonly used surgical procedure for the treatment of cartilage defects but often leads to fibrocartilage repair. The aim of this study is to compare the effects of 5 bone morphogenetic proteins (BMPs) on chondrogenic differentiation of human bone marrow mesenchymal stem cells, as well as to investigate the use of the heparin/poly (ethylene arginine aspartate diglyceride (PEAD) coacervate sustained release system to deliver these BMPs for microfracture-mediated cartilage repair. Our results indicate that all 5 human BMPs significantly enhance the chondrogenic differentiation of human bone marrow mesenchymal stem cells (hBMMSCs) with BMPs 2,4 and 9 being more potent than BMP6 or BMP7, as revealed by Alcian blue, SO staining, and immunohistochemistry of COL2. Coacervate-BMPs are biocompatible for both hBMMSCs and rat muscle-derived stem cells (MDSCs) and promote their proliferation.
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Registered trials
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