Evidence map›Paper›PMID 40607070›Full record

ReviewImaging science in dentistry2025

Diffusion-weighted magnetic resonance imaging for differentiation of unicystic ameloblastoma, odontogenic keratocyst, and dentigerous cyst: A systematic review and network meta-analysis.

Medhana Mangaonker, Shamli Prabhu Chodnekar, Manisha M Khorate, Nigel Figueiredo, Miyola Cia Fernandes, Sushmita Wayadande

Abstract readReview
In one paragraph

Review in Imaging science in dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Medhana MangaonkerDepartment of Oral Medicine and Radiology, Goa Dental College and Hospital, Bambolim, India.ORCID https://orcid.org/0009-0001-8511-9400
Shamli Prabhu ChodnekarDepartment of Oral Medicine and Radiology, Goa Dental College and Hospital, Bambolim, India.ORCID https://orcid.org/0009-0006-0359-5777
Manisha M KhorateDepartment of Oral Medicine and Radiology, Goa Dental College and Hospital, Bambolim, India.ORCID https://orcid.org/0000-0003-3828-585X
Nigel FigueiredoDepartment of Oral Medicine and Radiology, Goa Dental College and Hospital, Bambolim, India.ORCID https://orcid.org/0000-0002-7306-1205
Miyola Cia FernandesAsian Development Research Institute, Patna, India.ORCID https://orcid.org/0000-0003-0477-2836
Sushmita WayadandeDepartment of Oral Medicine and Radiology, Goa Dental College and Hospital, Bambolim, India.ORCID https://orcid.org/0009-0002-7500-0665

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Diffusion-weighted magnetic resonance imaging (DW-MRI) facilitates the differentiation of unicystic ameloblastoma (UAM), odontogenic keratocyst (OKC), and dentigerous cyst (DC) by depicting detailed internal lesion structures based on water molecule movement. This study aimed to evaluate the efficacy of DW-MRI in distinguishing UAM, OKC, and DC. Materials and Methods: This systematic review included studies from 2008 to 2022 that evaluated the diagnostic accuracy of DW-MRI through apparent diffusion coefficient (ADC) values in UAM, OKC, and DC. Six studies were qualitatively appraised using the QUADAS-2 tool, and 4 studies were subsequently included in a network meta-analysis for quantitative assessment of mean ADC values. The protocol was registered with PROSPERO (registration number: CRD42024502152). Results: Six studies encompassing 230 patients employed DW-MRI with an echo planar imaging sequence, yielding images with either hyperintense or hypointense lesion enhancements. The studies demonstrated that the mean ADC value for UAM was >2.0×10 Conclusion: This systematic review shows that DW-MRI, when used in conjunction with ADC measurements, effectively differentiates among UAM, OKC, and DC. The statistically significant ADC cut-off values support the use of DW-MRI as an adjunctive imaging modality to improve diagnostic accuracy in clinical practice.

Indexed as

AmeloblastomaDentigerous CystDiffusion Magnetic Resonance ImagingOdontogenic Cysts

Identifiers

PMID40607070
PMCPMC12210118

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.