ReviewImaging science in dentistry2025
Using fractal analysis to assess periapical bone formation after endodontic treatment: A systematic review and meta-analysis.
Review in Imaging science in dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07307807 (Evaluation of Postoperative Pain and Lesion Healing in Periapical Lesion-Affected Teeth Obturated With Different Root Canal Sealers), which is not on this map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Postoperative Pain and Lesion Healing in Periapical Lesion-Affected Teeth Obturated With Different Root Canal Sealers: Prospective Study
Who cites it
5 citing papers in PubMed.
- Fractal analysis in dentistry: a bibliometric analysis (1991-2024).Oral radiology · 2026Article
- A methodological framework for fractal analysis in monitoring periapical lesions after endodontic retreatment: a comprehensive parameter optimization study.BMC oral health · 2026Article
- Comparative Molecular Effects of Dexmedetomidine and Propofol on Osteoblast Migration and Osteogenic Gene Expression at Pediatric-Equivalent Concentrations: An In Vitro Study.Current issues in molecular biology · 2026Article
- Do Laser-Activated Irrigation Protocols Improve Endodontic Success? A Prospective Clinical Comparison of 1-Year Periapical Healing with Sonic, Ultrasonic, Manual Dynamic and Conventional Techniques.Diagnostics (Basel, Switzerland) · 2026Article
- Effect of Regenerative Endodontic Treatment on Bone Structure in Children: A Fractal Analysis Approach.Medicina (Kaunas, Lithuania) · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study aimed to review, evaluate, and synthesize existing evidence on the effectiveness of fractal analysis (FA) in assessing bone formation in periapical lesions following endodontic treatment. Materials and Methods: Two reviewers systematically searched 6 electronic databases and gray literature. Studies were deemed eligible if they implemented the desired intervention and included a follow-up period of at least 12 months. Methodological quality was assessed using tools from the Joanna Briggs Institute. The meta-analysis calculated the mean difference (MD) in FA measurements of periapical lesion regions before and after endodontic treatment, with subgroup analyses based on bone and treatment type. The GRADE tool was employed to evaluate the certainty of the evidence. Results: Ten studies were included for qualitative synthesis and 8 in the meta-analysis. Overall, the mean fractal dimension (FD) increased following 12 months of endodontic treatment, with an MD of 0.223 (95% CI: 0.100-0.346; Conclusion: The observed increase in mean FD 12 months post-endodontic treatment across all included studies indicates bone formation in the periapical lesion regions.
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Registered trials
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