ArticleFrontiers in molecular biosciences2025
The prognostic value of admission serum uric acid for acute kidney injury: a two-center retrospective analysis.
Article in Frontiers in molecular biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Acute kidney injury (AKI) is a serious clinical syndrome, with elevated serum uric acid (SUA) recognized as a potential modifiable risk factor. Nonetheless, the association between reduced SUA and the risk of AKI, along with the modification by kidney function on this association, is not well understood. Methods: All adult patients from Peking University First Hospital (PKUFH) were screened. The primary outcome was AKI during hospitalization. Restricted cubic spline (RCS) was utilized to examine the hypothesized non-linearity between AKI and SUA as a continuous variable. SUA was categorized into six groups and Poisson regression was applied to evaluate the association between SUA groups and AKI with 240-360 μmol/L as reference. Subgroup analysis was conducted in terms of estimated glomerular filtration rate (eGFR). Results: Among 62,775 patients enrolled from PKUFH, 1,866 patients developed AKI (3.0%). The RCS plot showed a U-shaped association between SUA and AKI. Compared with reference group, SUA ≤ 180 μmol/L and >480 μmol/L exhibited a 2.17-fold and a 4.86-fold increased risk of AKI in the unadjusted model. After full adjustment, the associated risk of AKI in SUA ≤ 180 μmol/L (RR 1.92, 95% CI 1.57-2.36) and SUA > 480 μmol/L (RR 1.17, 95% CI 1.03-1.34) was weakened but still demonstrated statistical significance. When stratified by eGFR, the U-shaped risk curve was much less steep in the subgroup with eGFR ≤ 45 mL/min/1.73 m Conclusion: This study reveals a U-shaped association between admission SUA and AKI risk. Kidney function is an important confounder for this association.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.