ArticleFrontiers in nutrition2025
Objective nutritional indices as an independent predictor of functional outcome after endovascular therapy for acute ischemic stroke: a cohort study in a Chinese population.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Article
- A novel evaluation indicator for pediatric fulminant myocarditis: diagnostic and prognostic value of the HALP score.BMC pediatrics · 2026Article
- Prognostic value of objective nutritional indices (PNI, CONUT, and HALP) for in-hospital all-cause mortality in surgically treated infective endocarditis: a 14-year retrospective study in a Chinese cohort.Frontiers in nutrition · 2026Article
- Association between PNI and all-cause mortality in ischemic stroke patients: a large-scale retrospective cohort study.Frontiers in nutrition · 2026Article
- The prognostic nutritional index (PNI) and sepsis-induced cardiomyopathy (SCM) risk in the ICU: a retrospective study with L-shaped analysis.Frontiers in nutrition · 2026Article
- Association of Serum Fetuin-B with Large-Artery Atherosclerotic Acute Ischemic Stroke and Functional Outcome.International journal of general medicine · 2026Article
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Abstract
Objective: To investigate the associations between three nutritional indices-Prognostic Nutritional Index (PNI), Controlling Nutritional Status (CONUT) score, and Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) score-and 90-day functional outcomes in patients with large vessel occlusion acute ischemic stroke (LVO-AIS) who underwent endovascular therapy (EVT). Methods: In this retrospective cohort study, we consecutively enrolled 409 LVO-AIS patients who received EVT at a comprehensive stroke center between January 2019 and December 2024. The primary endpoint was poor functional outcome, defined as a modified Rankin Scale (mRS) score of 3-6 at 90 days. Associations between nutritional indices and functional outcomes were analyzed using multivariable logistic regression models with stepwise adjustment. Restricted cubic spline (RCS) analysis was performed to explore potential non-linear relationships. Subgroup analyses with interaction tests assessed the consistency of these associations across demographic and clinical subgroups. Results: At 90-day follow-up, 261 patients (63.8%) had poor functional outcomes. The prevalence of malnutrition risk varied substantially between nutritional indices: PNI identified 15.9% of patients at risk, whereas the CONUT scoring system classified 81.9% of patients as having some degree of malnutrition risk. After comprehensive adjustment for confounders, each one-unit increase in PNI was associated with a 6% reduction in the risk of poor outcomes (adjusted OR = 0.94, 95% CI: 0.89-0.99, Conclusion: Prognostic Nutritional Index and HALP scores serve as independent predictors of poor 90-day functional outcomes in LVO-AIS patients treated with EVT. The significant non-linear relationship observed between HALP score and functional outcomes suggests that interventions targeting patients with moderate to severe malnutrition risk may yield greater clinical benefits.
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