Evidence map›Paper›PMID 40607006›Full record

ArticleClinical and translational radiation oncology2025

Evaluation of therapeutic radiographer target volume contouring for magnetic resonance image guided online adaptive bladder radiotherapy.

Bethany Williams, Jonathan Mohajer, Sophie E Alexander, Helen Barnes, Francis Casey, Joan Chick, Alex Dunlop, Ryan Fullerton, Trina Herbert, Robert Huddart and 7 more

Abstract read
In one paragraph

Article in Clinical and translational radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Bethany WilliamsThe Royal Marsden NHS Foundation Trust, London, UK.
Jonathan MohajerThe Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, UK.
Sophie E AlexanderThe Royal Marsden NHS Foundation Trust, London, UK.
Helen BarnesThe Royal Marsden NHS Foundation Trust, London, UK.
Francis CaseyThe Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, UK.
Joan ChickThe Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, UK.
Alex DunlopThe Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, UK.
Ryan FullertonThe Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, UK.
Trina HerbertThe Royal Marsden NHS Foundation Trust, London, UK.
Robert HuddartThe Institute of Cancer Research/The Royal Marsden NHS Foundation Trust, London, UK.
Sarah A MasonThe Institute of Cancer Research/The Royal Marsden NHS Foundation Trust, London, UK.
Adam MitchellThe Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, UK.
Jayde NarteyThe Royal Marsden NHS Foundation Trust, London, UK.
Simeon NillThe Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, UK.
Priyanka PatelThe Royal Marsden NHS Foundation Trust, London, UK.
Shaista HafeezThe Institute of Cancer Research/The Royal Marsden NHS Foundation Trust, London, UK.
Helen A McNairThe Institute of Cancer Research/The Royal Marsden NHS Foundation Trust, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: One barrier to wider clinical implementation of online MRI-guided radiotherapy (MRIgRT) on the MR Linac (MRL) is resource intensity. Specifically, the requirement for a clinical oncologist/radiation oncologist (CO/RO) to perform online contouring each fraction. We report an evaluation of therapeutic radiographer (RTT) online contouring for patients receiving whole bladder MRIgRT. Materials and methods: RTTs undertook a contouring training programme. RTT and CO/RO clinical target volume (CTV) contours from 95 fractions were assessed using dice similarity coefficient (DSC), hausdorff distance (HD), mean distance to agreement (MDA), sensitivity and specificity volume metrics on the Raystation treatment planning system (TPS) (RaySearch Laboratories). Additionally, CTV DSC was evaluated with respect to a simultaneous truth and performance level estimation (STAPLE) generated in ADMIRE (Elekta AB, Stockholm, Sweden). In dosimetric analysis (Monaco, Elekta AB), online adaptive treatment plans, which had been generated using RTT-defined contours, were evaluated using contours delineated offline by CO/ROs. Results: Comparison of RTT versus CO/RO contours found the CTV median (interquartile range) (IQR) for DSC was 0.92 (0.91-0.94), MDA was 0.11 (0.09-0.12) cm, and HD was 0.63 (0.53-0.72) cm, sensitivity and specificity were 0.94 (0.90-0.96) and 0.95 (0.92-0.97) respectively. In dosimetric analysis, 65 % (30/46) plans met optimal PTV coverage of V52.25 Gy > 98 % and all plans met mandatory PTV coverage of V52.25 Gy > 95 %. Conclusion: Following effective training, evaluation results demonstrate RTT whole bladder CTV contours to be comparable to CO/RO contours. Clinical implementation will release CO/ROs from MRL bladder treatments, reducing resource intensity of online workflows.

Indexed as

MR LinacOnline adaptive bladder radiotherapyRTT contouring

Identifiers

PMID40607006
PMCPMC12214246

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.