Evidence map›Paper›PMID 40607003›Full record

ArticleFrontiers in oncology2025

Human annexin A5 promotes glioma progression by targeting the

WeiXian Liu, Tao Xiong, Hu Sun, Ming Wang, JunGao Zhu, ChuanChuan Li

Abstract read
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Schisandrin B targets CD44 to inhibit glioblastoma multiforme.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

WeiXian LiuDepartment of Neurosurgery, Zhejiang Hospital, Zhejiang, China.
Tao XiongDepartment of Neurosurgery, Zhejiang Hospital, Zhejiang, China.
Hu SunDepartment of Neurosurgery, Zhejiang Hospital, Zhejiang, China.
Ming WangDepartment of Neurosurgery, Zhejiang Hospital, Zhejiang, China.
JunGao ZhuDepartment of Orthopaedics, Zhejiang Hospital, Zhejiang, China.
ChuanChuan LiDepartment of Thoracic surgery, Zhejiang Hospital, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Gliomas are the most common intracranial malignant tumors. In this study, we aimed to identify the hub genes and investigate the pathophysiological significance of Methods: The differentially expressed genes (DEGs) between tumor and adjacent tissues from glioma patients were acquired from the Gene Expression Omnibus (GEO) database. Functional enrichment analysis and protein-protein interaction (PPI) network construction of overlapping DEGs were performed. The GEPIA and CGGA databases were used to explore hub gene expression. The effect of hub genes on prognosis and tumor-infiltrating immune cells was analyzed via GEPIA, CGGA, and TIMER2 databases. Additionally, Results: The DEGs were enriched in cell surface receptor signaling pathway, immune response, and Conclusion: Taken together, our data showed that

Indexed as

anxa5CD44gene expression omnibusgliomaMAPK

Identifiers

PMID40607003
PMCPMC12213820

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.