ArticleEuropean heart journal. Imaging methods and practice2025
Anterior mitral valve leaflet length and response to mavacamten in obstructive hypertrophic cardiomyopathy.
Article in European heart journal. Imaging methods and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Left ventricular flow components and myocardial deformation following treatment for hypertrophic obstructive cardiomyopathy: a retrospective cardiac magnetic resonance-based cohort of mavacamtenCardiovascular diagnosis and therapy · 2026Article
- Mavacamten in the Treatment of Obstructive Hypertrophic Cardiomyopathy: from Pathophysiology To Real World Data.Current cardiology reports · 2025Review
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Authors and funding
12 authors.
Funding
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Abstract
Objectives: This study examines whether anterior mitral valve leaflet (AMVL) length is associated with response to mavacamten in patients with obstructive hypertrophic cardiomyopathy (HCM). Aims: Obstruction of the left-ventricular outflow tract (LVOT) in HCM has been associated with asymmetric septal hypertrophy and abnormalities of the mitral valve and sub-valvular apparatus. Mavacamten is a myosin-inhibitor shown to decrease LVOT gradient and improve functional status in patients with obstructive HCM. Methods and results: Measurements of cardiac structural elements were obtained from magnetic resonance imaging and echocardiography data among patients with obstructive HCM treated with mavacamten. Endpoints were effective mavacamten dose, defined as the dose required to achieve a Valsalva LVOT gradient <30 mmHg, and rapid response to mavacamten therapy, defined as achieved Valsalva LVOT gradient <20 mmHg within 8 weeks of initiation. Among 33 patients, patients with an effective dose of 5 mg ( Conclusion: Shorter AMVL length is associated with a lower effective dose and a rapid response to mavacamten. If confirmed in larger studies, AMVL length may inform optimal dosing of myosin inhibitors in obstructive HCM.
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