Evidence map›Paper›PMID 40606917›Full record

ArticleWorld journal of hepatology2025

Diagnostic performance of Liver FibraChek Dx

Fernando Siguencia, Michitaka Matsuda, Vijay Pandyarajan, Sunao Tanaka, Steven M Smith, Catherine Bresee, Ekihiro Seki, Charles J Rosser, Hideki Furuya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fernando SiguenciaSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.
Michitaka MatsudaDivision of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.
Vijay PandyarajanDivision of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.
Sunao TanakaSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.
Steven M SmithSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.
Catherine BreseeDepartment of Biostatistics Shared Resources, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.
Ekihiro SekiDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.
Charles J RosserSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.
Hideki FuruyaDepartment of Biomedical Science, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States. hideki.furuya@cshs.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMetabolic dysfunction-associated steatotic liver disease (MASLD), hepatic fibrosis, and cirrhosis are major risk factors for hepatocellular carcinoma (HCC), yet current blood-based diagnostic assays lack sufficient accuracy for routine clinical use. Identifying a non-invasive molecular signature that accurately detects liver disease could improve early diagnosis and monitoring. We hypothesized that the Liver FibraChek Dx

aimTo evaluate the diagnostic performance of the Liver FibraChek Dx

methodsThis was a prospective, single-center study conducted in a United States tertiary care setting. Serum samples were collected from 45 participants (14 MASLD, 19 HCC, 12 healthy controls) with liver histology confirmed by biopsy. The Liver FibraChek Dx

resultsLiver FibraChek Dx

conclusionThe Liver FibraChek Dx

Indexed as

BiomarkersCirrhosisFibrosisHepatocellular carcinomaHigh pressure liquid chromatographyMetabolic dysfunction-associated steatotic liver diseaseMetabolomicsMultiplexPeripheral blood

Identifiers

PMID40606917
PMCPMC12210174

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.