ArticleFrontiers in bioengineering and biotechnology2025
Acellular porcine placental membranes as a novel biomaterial for tissue repair applications.
Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Biological dressings derived from the extracellular matrix (ECM) of human placental tissues have proven effective in treating complex skin wounds and other anatomical sites, offering potential for new therapeutic applications. However, the use of human tissues is limited by ethical and biosafety concerns, restricting large-scale production. To address this, biomaterials from placentas of livestock animals offer a cost-effective, accessible alternative without harming animal welfare. Given pigs' large-scale production, short gestation periods, and abundant material availability, this study aimed to produce, characterize, and validate acellular biomembranes derived from decellularized porcine allantochorion for tissue repair. Placental fragments from Duroc sows were decellularized using a protocol involving immersion and orbital shaking in 0.1% SDS and 0.5% Triton X-100, followed by low-frequency ultrasonication. Accelularity was confirmed by total genomic DNA quantification and H&E and DAPI staining for nuclear visualization. Membrane structure and composition were analyzed using histological, immunohistochemical methods, and scanning electron microscopy. Spectroscopic analyses detected physicochemical changes in placental ECM, and biomechanical testing assessed membrane strength and stiffness. Biological functionality was validated through
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