ArticleFrontiers in psychology2025
Defense mechanisms in immune-mediated diseases: a cross-sectional study focusing on Severe Allergic Asthma and Hymenoptera Venom Anaphylaxis patients.
Article in Frontiers in psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Health-related quality of life and patterns of psychological vulnerability in autoimmune Addison's disease: a systematic review.Frontiers in endocrinology · 2026Pooled it
- EGPA at Diagnosis: A Comprehensive Single-Center Profile of Laboratory Findings and Clinical Evidence.International journal of molecular sciences · 2026Article
- Personality, Emotion Regulation, and Psychological Distress in Italian Women with Feeding and Eating Disorders: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- The Role of Artificial Intelligence in Shaping the Doctor-Patient Relationship: A Narrative Review.Healthcare (Basel, Switzerland) · 2026Review
- A Two-Year Pharmacovigilance Analysis of Adverse Drug Reactions Reported from a University Allergy Setting.Journal of clinical medicine · 2026Article
- Editorial: Anaphylaxis challenges: idiopathic and rare causes.Frontiers in allergy · 2026Article
- Clinical applications of the Defense Mechanisms Rating Scale-Self-Report-30: a systematic review of the first five years.Research in psychotherapy (Milano) · 2025Article
- Applying the Defense Mechanisms Rating Scales Q-sort to assess patients' level of overall defensive functioning in interview data: validity and reliability.Research in psychotherapy (Milano) · 2025Article
- Type 1 Diabetes Mellitus and Alexithymia: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
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13 authors.
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Abstract
Background: Chronic immune-mediated diseases, such as Severe Allergic Asthma (SAA) and Hymenoptera Venom Anaphylaxis (HVA), significantly impact quality of life. Defense mechanisms, as implicit emotion-regulation strategies, shape an individual's adaptation to chronic stressors. This cross-sectional study explored the relationship among defensive functioning, psychological symptoms, and perceived physical and mental health in patients with SAA and HVA. Methods: To explore the role of defensive functioning in perceived physical and mental health 34 patients with SAA and 32 with HVA were assessed with the Short-Form Health Survey, the Beck Depression Inventory, the Hamilton Anxiety Rating Scale, the Toronto Alexithymia Scale, and the Defense Mechanisms Rating Scales Self Report-30; between-group differences, and mediation analyses were performed. Results: Defensive functioning was positively associated with mental health and negatively related to depressive symptoms, anxiety and alexithymia. Males reported significantly higher physical and psychological health than females. Patients with SAA exhibited significantly higher defensive functioning but worse physical health than HVA patients. Mediation analysis revealed that defensive functioning correlated with disease type and physical health, accounting for 39% of the explained variances. Moreover, defensive functioning independently predicted mental health. Conclusion: This study highlights the influence of implicit emotional regulation on psychophysiological well-being in patients with chronic immune-mediated disorders. Despite reporting lower perceived physical health, patients with SAA exhibited higher defensive functioning, suggesting that chronic conditions may shape distinct psychological adaptation processes. These findings support the importance of defence mechanisms assessment to tailor psychological interventions promoting well-being in patients with chronic diseases.
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