ArticleFrontiers in neuroscience2025
A magnetic resonance imaging and gut flora-based study of intake desire in overweight/obese type 2 diabetes mellitus patients.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Hybrid PET/fMRI reveals interactive effects of T2DM and MCI on cerebral glucose metabolism and ALFF.Frontiers in endocrinology · 2026Article
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10 authors.
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Abstract
Background: Abnormal regulation of food intake in overweight/obese type 2 diabetes mellitus (T2DM) patients is an important cause of energy intake imbalance, and studies have demonstrated that the "gut-brain axis" is involved in a wide range of metabolic regulation through neural and endocrine processes, which has become a key breakthrough in revealing the abnormalities of food intake behaviors in T2DM patients. Objective: Exploring the mechanism of action of abnormal regulation of ingestive desire in overweight/obese T2DM patients by integrating multimodal MRI techniques with microbiological analysis based on the gut-brain axis. Methods: Thirty-one patients with overweight/obese type 2 diabetes mellitus (Group A), 17 patients with simple obesity with abnormal glucose metabolism (Group B), and 14 patients with simple obesity with normal glucose metabolism (Group C) were recruited, and clinical data, MRI, and stool specimens were collected to analyze the correlation between the imaging indicators and the intestinal flora, and clinical data. Results: Compared with Group C, the abundance of Conclusion: Abnormal desire to ingest is the result of functional changes in brain regions, dysregulation of flora metabolism and neuroimmune interactions, providing a theoretical basis for clinical diagnosis and treatment targeting the gut-brain axis.
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