Evidence map›Paper›PMID 40606757›Full record

ArticleiScience2025

Randomized controlled trial of prednisone in treating acute subjective tinnitus patients with normal pure-tone thresholds.

Peifan Li, Chenhao Che, Dantong Gu, Xiaoling Lu, Xiao Xiao, Yanping Yu, Dongmei Tang, Dan You, Tingting Qian, Yongzhen Wu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Peifan LiENT Institute and Department of Otorhinolaryngology, NHC Key Laboratory of Hearing Medicine Research, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.
Chenhao CheENT Institute and Department of Otorhinolaryngology, NHC Key Laboratory of Hearing Medicine Research, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.
Dantong GuENT Institute and Department of Otorhinolaryngology, NHC Key Laboratory of Hearing Medicine Research, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.
Xiaoling LuENT Institute and Department of Otorhinolaryngology, NHC Key Laboratory of Hearing Medicine Research, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.
Xiao XiaoENT Institute and Department of Otorhinolaryngology, NHC Key Laboratory of Hearing Medicine Research, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.
Yanping YuDepartment of Otolaryngology, Shenzhen Second People's Hospital, Shenzhen, China.
Dongmei TangENT Institute and Department of Otorhinolaryngology, NHC Key Laboratory of Hearing Medicine Research, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.
Dan YouENT Institute and Department of Otorhinolaryngology, NHC Key Laboratory of Hearing Medicine Research, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.
Tingting QianENT Institute and Department of Otorhinolaryngology, NHC Key Laboratory of Hearing Medicine Research, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.
Yongzhen WuENT Institute and Department of Otorhinolaryngology, NHC Key Laboratory of Hearing Medicine Research, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.
Shan SunENT Institute and Department of Otorhinolaryngology, NHC Key Laboratory of Hearing Medicine Research, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effectiveness of steroid therapy for acute subjective tinnitus (AST) without sudden hearing loss remains controversial. This randomized controlled trial evaluated the effectiveness of short-term oral prednisone (STOP) in patients with AST. The STOP group received a 14-day tapering prednisone for the initial 14 days, and both groups took Ginkgo biloba extract throughout the 3-month follow-up period. The primary outcome was the 12-week change in Tinnitus Handicap Inventory (THI) scores, assessed via intention-to-treat analysis. At the 12-week follow-up, the STOP medication significant reduced THI scores (-27 · 34 [95% CI, -31 · 14 to -23 · 55]) versus control (-15 · 37 [95% CI, -18 · 5 to -12 · 23]), with a mean difference of -11 · 97 points (95% CI, -16 · 85 to -7·09;

Indexed as

Clinical neuroscienceTherapeutics

Identifiers

PMID40606757
PMCPMC12221516

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.