Evidence map›Paper›PMID 40606631›Full record

ArticleFrontiers in cellular and infection microbiology2025

Evidence for the role of Irk2 and Irk5 in ATP and metabolism regulation in

Yuanyuan Ma, Jianhua Qu, Mingming Xu, Nuoya Zhou, Xiaoya Chen, Yu Han, Peng Xue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuanyuan Ma *Nantong Key Laboratory of Environmental Toxicology, Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong, China.
Jianhua Qu *Nantong Key Laboratory of Environmental Toxicology, Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong, China.
Mingming Xu *Wisdom Lake Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China.
Nuoya ZhouWisdom Lake Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China.
Xiaoya ChenWisdom Lake Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China.
Yu HanNantong Key Laboratory of Environmental Toxicology, Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong, China.
Peng XueNantong Key Laboratory of Environmental Toxicology, Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: To investigate the impact of Results: Mass spectrometry analyses revealed significant alterations in protein and metabolite expression levels in the Conclusion: This study suggests that the core virulence kinases Irk2 and Irk5 may play roles in regulating ATP levels and metabolic pathways. By elucidating the effects of these kinases on the proteomic and metabolomic profiles of

Indexed as

Adenosine TriphosphateCryptococcus neoformansFungal ProteinsProtein KinasesCryptococcosisGene DeletionGene Expression Regulation, FungalHumansMass SpectrometryMelaninsMetabolomicsProteomeProteomicsVirulenceVirulence FactorsAdenosine TriphosphateFungal ProteinsMelaninsProtein KinasesProteomeVirulence FactorsATPcryptococcosisIrk2Irk5metabolomicsproteome

Identifiers

PMID40606631
PMCPMC12214898

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.