ArticleFrontiers in pharmacology2025
Investigating the underlying mechanisms of the ethanol extract of saussureae involucratae herba in anti-rheumatoid arthritis effect based on sphingolipidomics.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Article
- Integrative transcriptomics-metabolomics reveals sphingolipid metabolic reprogramming in traditional Chinese medicine syndrome differentiation of rheumatoid arthritis.Frontiers in immunology · 2026Article
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7 authors.
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Abstract
Introduction: Saussureae Involucratae Herba (SIH), a traditional Chinese Medicine, is clinically used in treating rheumatoid arthritis (RA). However, the anti-RA mechanisms of SIH remain unclear. Dysregulation of sphingolipid metabolism is related to the pathogenesis of RA. This study aims to investigate whether the regulation of sphingolipid metabolism is involved in the anti-RA effects of an ethanol extract of SIH (SIE). Methods: The collagen-induced arthritis (CIA) mouse model and LPS-stimulated RAW 264.7 cells were used. Targeted sphingolipidomics were employed to investigate the effects of SIE on the regulation of sphingolipid metabolism in CIA mice. Results: Results showed that SIE significantly reduced arthritis scores and the average thickness of the four paws (both Discussion: We, for the first time, found that SIE has anti-RA effects in CIA mice and that regulation of sphingolipid metabolism is involved in its anti-RA action. These findings provide pharmacological evidence for the use of SIH in managing RA and support the theory that targeting sphingolipid metabolism is a strategy for treating RA.
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