ArticleFrontiers in pharmacology2025
Knowledge graph and emerging trends in oxidative stress research on hepatic ischemia-reperfusion injury: a bibliometric analysis (1995-2024).
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Research Trends in Neutrophil Extracellular Traps and Ischemia-Reperfusion Injury: A Dual-Database Bibliometric Analysis from 2013 to 2025.Journal of inflammation research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hepatic ischemia-reperfusion injury (HIRI) is a common complication in surgical procedures such as liver transplantation and extensive hepatectomy, characterized by an ischemic or hypoxic phase followed by reperfusion. Oxidative stress, primarily resulting from an imbalance between the generation and clearance of reactive oxygen species (ROS), plays a pivotal role in HIRI pathogenesis and has garnered significant research attention. Objective: This bibliometric analysis comprehensively reviews global research trends and priorities in the study of oxidative stress in HIRI from 1995 to 2024, providing valuable insights and guidance for future researchers. Methods: We conducted a systematic bibliometric analysis of relevant publications indexed in the Web of Science Core Collection (1995-2024), employing specific search qualifiers. Analyses were performed using CiteSpace (version 6.2.R6) and VOSviewer (version 1.6.20). Results: Final analysis included 2,367 publications. Over the past three decades, annual publication numbers in this field have consistently risen. China, the United States, and Turkey emerged as the leading contributing countries. Wuhan University, Sun Yat-sen University, and Shanghai Jiao Tong University ranked as the top three institutions by publication volume. The Conclusion: Our findings indicate a shift in research focus from elucidating fundamental mechanisms towards exploring therapeutic interventions and associated protective effects. Nanotechnology and epigenetic modifications represent promising future avenues for treating HIRI in the therapeutic domain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.