Evidence map›Paper›PMID 40606587›Full record

ArticleNeurobiology of pain (Cambridge, Mass.)

Enhanced trafficking of an inherited erythromelalgia Na

Malgorzata A Mis, Sidharth Tyagi, Elizabeth J Akin, Mohammad-Reza Ghovanloo, Peng Zhao, Fadia Dib-Hajj, Andrew D Randall, Stephen G Waxman, Sulayman D Dib-Hajj

Abstract read
In one paragraph

Article in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Malgorzata A MisDepartment of Neurology, Yale University, New Haven, CT 06510, USA.
Sidharth TyagiDepartment of Neurology, Yale University, New Haven, CT 06510, USA.
Elizabeth J AkinDepartment of Neurology, Yale University, New Haven, CT 06510, USA.
Mohammad-Reza GhovanlooDepartment of Neurology, Yale University, New Haven, CT 06510, USA.
Peng ZhaoDepartment of Neurology, Yale University, New Haven, CT 06510, USA.
Fadia Dib-HajjDepartment of Neurology, Yale University, New Haven, CT 06510, USA.
Andrew D RandallUniversity of Exeter Medical School, Exeter EX2 5DW, UK.
Stephen G WaxmanDepartment of Neurology, Yale University, New Haven, CT 06510, USA.
Sulayman D Dib-HajjDepartment of Neurology, Yale University, New Haven, CT 06510, USA.

Funding

Medical Scientist Training ProgramT32GM136651 · NIGMS · YALE UNIVERSITY · PI BARBARA I KAZMIERCZAK · 2020 to 2026
$16.5M
Targeted degradation of NaV1.8 as a therapeutic strategy for painF31NS135909 · NINDS · YALE UNIVERSITY · PI TYAGI, SIDHARTH · 2024 to 2024
$32k
NIGMS NIH HHS T32 GM136651NINDS NIH HHS F31 NS135909RRD VA I50 RX002999
6 · The paper itself

Abstract

Gain-of-function mutations which enhance activation of Na

Indexed as

Live fluorescent imagingPatch-clamp recordingsSensory neurons

Identifiers

PMID40606587
PMCPMC12221430

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.