Evidence map›Paper›PMID 40606519›Full record

ArticleJournal of molecular and cellular cardiology plus2025

Blueprint of the distinct metabolite profiles of healthy pig heart chambers.

Retu Haikonen, Topi Meuronen, Ville Koistinen, Olli Kärkkäinen, Tomi Tuomainen, Gloria I Solano-Aguilar, Joseph F Urban, Marko Lehtonen, Pasi Tavi, Kati Hanhineva

Abstract read
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In one paragraph

Article in Journal of molecular and cellular cardiology plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Retu HaikonenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Topi MeuronenFood Sciences Unit, Department of Life Technologies, University of Turku, Finland.
Ville KoistinenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Olli KärkkäinenSchool of Pharmacy, University of Eastern Finland, Kuopio, Finland.
Tomi TuomainenA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Gloria I Solano-AguilarU.S Department of Agriculture, Agricultural Research Service, Northeast Area, Beltsville Human Nutrition Research Center, Diet Genomics and Immunology Laboratory, Beltsville, MD, United States.
Joseph F UrbanU.S Department of Agriculture, Agricultural Research Service, Northeast Area, Beltsville Human Nutrition Research Center, Diet Genomics and Immunology Laboratory, Beltsville, MD, United States.
Marko LehtonenSchool of Pharmacy, University of Eastern Finland, Kuopio, Finland.
Pasi TaviA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Kati HanhinevaInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The heart is one of the most studied organs, with physiological processes and disease research. While it is well-established that significant structural and functional differences exist between the chambers, most studies focus on only a single heart chamber, predominantly the left ventricle. This study aims to comprehensively characterise the chamber-specific metabolic profiles of all four heart chambers in a healthy animal model close to human metabolism, pigs. We employed liquid chromatography-mass spectrometry metabolomics to analyse the metabolite profiles of heart chambers in healthy pigs (

Indexed as

ChambersHealthy heartMetabolomic profilesMetabolomics

Identifiers

PMID40606519
PMCPMC12221441

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.