ArticleAmerican journal of preventive cardiology2025
The influence of high exercise levels on the coronary atherosclerosis profile by computed tomography angiography and outcomes.
Article in American journal of preventive cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Risk Factors for Cardiovascular Disease: Epidemiology, Screening, Prevention, and Therapeutic Interventions.MedComm · 2026Review
- Exercise-Induced Coronary Remodeling and the Atherosclerotic Paradox in Endurance Athletes: Toward a Unified Mechanobiological Framework.Journal of functional morphology and kinesiology · 2026Review
- Self-Reported Habitual Daily Physical Activity as an Independent Predictor of Coronary Artery Disease Extension in Patients with Myocardial Infarction: A Prospective Observational Study.Journal of clinical medicine · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: High exercise volumes may have deleterious effects on the cardiovascular system, and the upper thresholds for "safe" volumes are unclear. Objective: To evaluate if high-exercise volumes influence the coronary artery disease (CAD) profile by coronary CTA, cardiovascular outcomes, compared with traditional CVRF. Methods: 802 patients (age 57.6 ± 10.95 years;38.1 % women) undergoing coronary CTA were enrolled. Self-reported exercise habits were collected: Type, volume (frequency/week and time/per unit); and years of training. Endpoints were: CTA: coronary stenosis severity (CADRADS); high-risk-plaque (HRP); coronary artery calcium score (CAC), and MACE. Results: 478 subjects were included. 100 with high-(H)-exercise level (>3-5x/week and 1-3 h per unit) were propensity-score matched with 124 sedentary controls. The CVRF dyslipidemia ( Conclusion: High-exercise levels (up to 9h/week) are safe - without a deleterious impact on the coronary atherosclerosis profile.
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