ArticleFrontiers in medicine2025
Life's Crucial 9 score and chronic kidney disease: insights from NHANES 2005-2018 and the mediating role of systemic inflammation and oxidative stress.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Association between healthy lifestyle and risk of chronic kidney disease: a prospective cohort study of 0.5 million Chinese adults.BMC public health · 2026Article
- Association of Life's Crucial 9 Score With Liver Fibrosis and Mortality in U.S. Adults With MASLD: Evidence From NHANES and the Mediating Role of Systemic Inflammation.Mediators of inflammation · 2026Article
- Association Between Cardiovascular Health (Life's Crucial 9) and Stress Urinary Incontinence in Women: The Mediating Role of Oxidative Stress Factors (NHANES 2005-2018).International journal of women's health · 2026Article
- The relationships between Life's Crucial 9, Life's Essential 8, and sarcopenia in older adults: multicenter case-control study.Frontiers in medicine · 2025Article
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Authors and funding
7 authors.
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Abstract
Background: Chronic kidney disease (CKD) is a growing global health burden, closely linked to metabolic and cardiovascular risk factors. Life's Crucial 9 (LC9) is a novel health assessment tool that expands upon Life's Essential 8 (LE8) by incorporating mental health (depression) as a key component. This study aimed to investigate the association between LC9 and CKD, compare its predictive value with LE8, and explore potential mediating mechanisms. Methods: This study analyzed data from 16,431 participants in the National Health and Nutrition Examination Survey (NHANES) 2005-2018. Logistic regression models were used to assess the association between LC9 and CKD, with comparisons to LE8. Restricted cubic spline models were applied to explore potential nonlinear relationships. Mediation analysis was conducted to evaluate whether systemic inflammation and oxidative stress mediated the association between LC9 and CKD. Receiver operating characteristic (ROC) analysis was performed to compare the predictive performance of LC9 and LE8 for CKD risk. Results: Higher LC9 scores were significantly associated with a lower risk of CKD in both continuous and quartile-based analyses. A nonlinear relationship was observed between LC9 and CKD risk ( Conclusion: Higher LC9 scores are associated with a reduced risk of CKD, with systemic inflammation and uric acid levels partially mediating this relationship. These findings highlight the importance of comprehensive lifestyle and mental health interventions in CKD prevention and management.
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