ArticleQuantitative imaging in medicine and surgery2025
Metabolic abnormalities in the insula of patients with interictal migraine without aura: a prospective cross-sectional study.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The insula plays a crucial role in the pathophysiology of patients with migraine without aura (MWoA), but the exact neurometabolic mechanisms are still unclear. This study aimed to explore possible neurometabolic mechanisms in the insula during the interictal period in MWoA patients, and neurometabolic differences between high frequency (HF) and law frequency (LF) headache patients via proton magnetic resonance spectroscopy ( Methods: A total of 22 MWoA patients and 22 age-, gender-, and education-matched healthy controls (HCs) were included in this prospective cross-sectional study. The subjects underwent routine T1-weighted imaging (T1WI) and single-voxel Results: During the interictal period of headache, the Ins (MWoA Conclusions: The dysfunction or loss of neurons and glial cells, and excitatory neurotransmitter conversion imbalance may be the key changes in the insula of interictal MWoA patients. HF headaches are characterized by hypometabolism, which may be caused by more serious mitochondrial dysfunction.
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