ArticleQuantitative imaging in medicine and surgery2025
Echocardiography derived-left atrial stiffness index as a more cost-effective and powerful approach compared to brain natriuretic peptide for predicting left atrioventricular uncoupling in patients with acute ischemic stroke.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Left Atrioventricular Coupling Index: A Comprehensive Review of the Literature.Life (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cardiac dysfunction and altered serum biomarker profiles may be associated with left atrioventricular uncoupling (LAU) in patients with acute ischemic stroke (AIS). This study sought to: (I) determine the key independent predictors from these cardiovascular and hematological parameters; and (II) systematically compare the predictive ability and cost-effectiveness in LAU risk stratification. Methods: A total of 207 patients with AIS who underwent real-time four-dimensional (4D) echocardiography and blood biomarker assay at admission were included in this study. LAU was diagnosed via 4D echocardiography when the left atrioventricular coupling index (LACI) was greater than 0.25. Multivariate logistic regression models were employed to identify the factors independently associated with LAU. A decision tree model was used to compare the cost-effectiveness of these factors. Results: LAU was found in 146 patients with AIS. These patients had higher levels of brain natriuretic peptide (BNP) and greater left atrial (LA) volume, stiffness, and function impairment than did those without LAU (P<0.05). According to multivariate logistic regression analysis, the two independent risk factors for LAU in patients with AIS were the LA stiffness index (LASI) [odds ratio (OR) =822.286; 95% confidence interval (CI): 25.487-182,900.741; P<0.0001] and BNP (OR =1.115; 95% CI: 0.998-1.246; P=0.031). In the prediction of LAU, the performance of LASI [area under the receiver operating characteristic curve (AUC) =0.772; sensitivity, 74.15%; specificity, 73.02%; cutoff value, 0.34] was superior to that of BNP (AUC =0.673; sensitivity, 70.55%; specificity, 60.66%; cutoff value, 39 pg/mL) (P<0.05). Moreover, the LASI echocardiographic measurement was a cost-effective tool for predicting LAU in patients with AIS. Conclusions: Both LASI and BNP demonstrated independent value for predicting LAU in the AIS cohort. LASI echocardiographic measurement can serve as a cost-effective approach for detecting LAU.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.