ArticleHealth science reports2025
Relationship Between Oxidative Stress and Severity of Diabetic Foot Ulcers Among Patients With Type-2 Diabetes Mellitus in Japan: A Cross-Sectional Study.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Delayed healing of diabetic foot ulcers (DFUs) is associated with significant morbidity, and oxidative stress (OS) induced by a diabetic state is considered an essential factor in the development of DFUs. Aims: To determine how systemic OS correlated with the severity of DFUs and to evaluate factors influencing OS in patients with type-2 diabetes mellitus. Methods: Purposive sampling was used to recruit 44 outpatients with type-2 diabetes (DM) from a hospital's foot care department and 32 attendees without DM from an elderly welfare centre in Japan. Participants' demographic data, medical history, fasting blood sugar, HbA1c, and ABI were assessed at every visit. Also, urinary malondialdehyde (MDA) concentrations were measured to indicate systemic OS. Results: Urinary MDA was higher in diabetic patients ( Conclusion: Higher systemic OS in a diabetic state and a strong correlation between wound severity and urinary MDA indicate that OS induced through several mechanisms relating to the diabetic state plays a vital role in DFU. Thus, OS can be a viable target for wound management in diabetic patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.