Complete remission of recurrent uterine angiosarcoma following long-term systemic chemotherapy with paclitaxel and carboplatin: A case report.

Angiosarcoma (AS) is a rare and aggressive malignancy of vascular endothelial origin, accounting for 2-5% of all soft tissue sarcomas. Primary uterine AS is extremely rare, with only ~30 cases reported in English literature. Its prognosis remains poor, with a 5-year survival rate of <35%, and there is currently no standard systemic chemotherapy established for unresectable or recurrent cases. This study presents the case of a 57-year-old woman with a 27×20 cm uterine mass causing severe anemia (hemoglobin 4.5 g/dl). Following total hysterectomy and bilateral salpingo-oophorectomy, histopathological analysis confirmed primary uterine AS (T1NXM0). Despite complete surgical resection, three new intra-abdominal tumors appeared within 1 month. The patient underwent 21 cycles of intravenous paclitaxel and carboplatin every 3-4 weeks, achieving complete disappearance of all metastatic lesions. The patient was still alive 31 months after the initial surgery without any sign of recurrence or metastasis. This case demonstrates the potential efficacy of paclitaxel and carboplatin combination chemotherapy for recurrent uterine AS, contributing valuable data to guide future therapeutic strategies for this rare malignancy with typically poor prognosis.