ArticleOncology letters2025
Cytological features of small cell neuroendocrine carcinoma of the uterine cervix.
Article in Oncology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Cervical Small Cell Neuroendocrine Carcinoma Initially Detected on Cytology: Diagnostic Pitfalls and Clues.Cytopathology : official journal of the British Society for Clinical Cytology · 2026Article
- Metaplastic-Like and Squamous Cell Carcinoma-Like Cells in Liquid-Based Cytology Associated With Small Cell Neuroendocrine Carcinoma of the Uterine Cervix.Cytopathology : official journal of the British Society for Clinical Cytology · 2026Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small cell neuroendocrine carcinoma (SCNEC) of the cervix is rare. Cytological examination is a valuable tool for detecting cervical lesions; however, due to the rarity of cervical SCNEC, its accurate diagnosis remains challenging. In some cases, cervical SCNEC coexists with other non-neuroendocrine components, forming what is known as combined SCNEC. The cytological features of combined SCNEC have not been well-documented. The present study retrospectively analysed the clinicocytological features of cervical SCNEC, including combined SCNEC. A total of six patients diagnosed with cervical SCNEC (three with pure SCNEC, two with combined SCNEC and one with carcinosarcoma) who underwent preoperative cervical cytological examination and were diagnosed with SCNEC through biopsy and/or surgical resection were included in the current study. The median patient age was 55 years, and the combined SCNEC cases included both SCNEC and adenocarcinoma components. Retrospective cytological examination revealed that cervical specimens from all six patients contained SCNEC components, characterised by clusters of small round neoplastic cells with round to oval nuclei, fine chromatin, and inconspicuous nucleoli in a necrotic or inflammatory background. Among the two patients with combined SCNEC, one exhibited an adenocarcinoma component, whereas the patient with carcinosarcoma had a sarcomatous component. These findings suggested that most cases of SCNEC can be detected in cervical cytological specimens. Additionally, other combined carcinoma components may be identified. Notably, careful cytological examination may facilitate the accurate diagnosis of cervical SCNEC, enabling timely treatment for this aggressive malignancy.
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