ReviewJHLT open2025
Sizing in lung transplantation: principles, practices and ideas for the future.
Review in JHLT open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Article
- Evaluation of Lung Volume Reduction in Patients with Interstitial Lung Disease Using Brainomix e-Lung.Journal of clinical medicine · 2026Article
- Chest wall strapping in a porcine model: Dynamic dysanapsis dilates airways for optimized function of the "oversized" lung.JHLT open · 2025Article
- Chest wall strapping in a porcine model: A model for the physiology of the oversized lung allograft.JHLT open · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lung transplantation (LTx) is an important treatment option for many end-stage lung diseases. The goal of LTx is to restore pulmonary physiology (gas exchange and respiratory system mechanics) towards normal, so that LTx recipients can experience an improved quality of life and live significantly longer. An optimized approach to donor-to-recipient size matching is a strategy to increase opportunities for successful transplants and optimize outcomes. In this review we discuss relevant pulmonary gas exchange and respiratory systems mechanics principles as a framework to optimize donor-to-recipient size matching and LTX-recipient management. The predicted total lung capacity (pTLC) is a refined estimate of organ size utilizing regression equations to calculate lung size based on height, sex and age. In general, irrespective of the underlying lung disease the chest cavity is "reverse remolding" back towards normal size in most recipients. The parameter that can reflect the sizing goal to restore physiology towards normal is the recipient pTLC. A pragmatic size matching metric is the donor-to-recipient pTLC-ratio. Significant undersizing based on the pTLC-ratio is a risk factor for complications and lower LTx survival. If significant changes to the LTx candidate's chest cavity size occur (as can occur in severe restrictive lung disease or severe emphysema), or if the chest cavity cannot "reverse remodel" towards normal, it is important to consider additional donor-to-recipient sizing metrics. In addition to the recipient's measured actual total lung capacity imaging-based metrics can be considered. Chest X-ray and computer tomography based volumetric analyses can provide information facilitating a successful LTx.
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Registered trials
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