ArticleFrontiers in cellular neuroscience2025
Average miniature post-synaptic potential size is inversely proportional to membrane capacitance across neocortical pyramidal neurons of different sizes.
Article in Frontiers in cellular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Motor learning and dopamine-dependent striatal synaptic plasticity are controlled by astrocytic MEGF10.Nature communications · 2026Article
- A novel method for reliably measuring miniature and spontaneous postsynaptic events in whole-cell patch clamp recordings in the central nervous system.Frontiers in cellular neuroscience · 2025Article
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Abstract
In chemical synapses of the central nervous system (CNS), information is transmitted via the presynaptic release of a vesicle (or 'quantum') of neurotransmitter, which elicits a postsynaptic electrical response with an amplitude termed the 'quantal size.' Measuring amplitudes of miniature postsynaptic currents (mPSCs) or potentials (mPSPs) at the cell soma is generally thought to offer a technically straightforward way to estimate quantal sizes, as each of these miniature responses (or minis) is generally thought to be elicited by the spontaneous release of a single neurotransmitter vesicle. However, in large highly-branched neurons, a somatically recorded mini is typically massively attenuated compared with at its input site, and a significant fraction are indistinguishable from (or canceled out by) background noise fluctuations. Here, using a new software package called 'minis,' we describe a novel quantal analysis method that estimates the effective 'electrical sizes' of synapses by comparing events detected in somatic recordings from the same neuron of (a)
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