Development and validation of a machine learning-based risk prediction model for stroke-associated pneumonia in older adult hemorrhagic stroke.

Objective: To develop and validate a machine learning (ML)-based model for predicting stroke-associated pneumonia (SAP) risk in older adult hemorrhagic stroke patients. Methods: A retrospective collection of older adult hemorrhagic stroke patients from three tertiary hospitals in Guiyang, Guizhou Province (January 2019-December 2022) formed the modeling cohort, randomly split into training and internal validation sets (7:3 ratio). External validation utilized retrospective data from January-December 2023. After univariate and multivariate regression analyses, four ML models (Logistic Regression, XGBoost, Naive Bayes, and SVM) were constructed. Receiver operating characteristic (ROC) curves and area under the curve (AUC) were calculated for training and internal validation sets. Model performance was compared using Delong's test or Bootstrap test, while sensitivity, specificity, accuracy, precision, recall, and F1-score evaluated predictive efficacy. Calibration curves assessed model calibration. The optimal model underwent external validation using ROC and calibration curves. Results: A total of 788 older adult hemorrhagic stroke patients were enrolled, divided into a training set ( Conclusions: This study constructed and validated a risk prediction model for SAP in older adult patients with hemorrhagic stroke based on multi-center data. The results indicated that among the four machine learning algorithms (XGBoost, LR, SVM, and Naive Bayes), the LR model demonstrated the best and most stable predictive performance. Age, smoking, low GCS score, low Braden score, and nasogastric tube were identified as predictive factors for SAP in these patients. These indicators are easily obtainable in clinical practice and facilitate rapid bedside assessment. Through internal and external validation, the model was proven to have good generalization ability, and a nomogram was ultimately drawn to provide an objective and operational risk assessment tool for clinical nursing practice. It helps in the early identification of high-risk patients and guides targeted interventions, thereby reducing the incidence of SAP and improving patient prognosis.