ArticleFrontiers in neurology2025
Association of systemic immune-inflammation index with severity in acute ischemic stroke patients: a cross-sectional study.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Systemic immune-inflammation index predicts hemorrhagic transformation after endovascular therapy for ischemic stroke.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Neurological Severity Versus Biomarker Dynamics in Post-Stroke Dysphagia: A Dual-Pathway Model for Functional Recovery and Feeding Transition.Journal of clinical medicine · 2026Article
- Combined nutritional and inflammatory risk stratification for predicting functional outcomes in acute ischemic stroke.Frontiers in nutrition · 2026Article
- Serum sCD163 as a potential biomarker for predicting poor functional outcome at 3 months in acute ischemic stroke without reperfusion: a prospective study.Frontiers in immunology · 2026Article
- FIB-4 Index, Systemic Inflammation, and Troponin Trajectory After Endovascular Thrombectomy in Older Patients with Large-Vessel Occlusion Stroke.Clinical interventions in aging · 2026Article
- The role of systemic immune-inflammation index in differentiation of juvenile idiopathic arthritis from reactive arthritis among Chinese children.Frontiers in medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the association between the Systemic Immune-Inflammation Index (SII) and the severity of acute ischemic stroke (AIS), as measured by the National Institutes of Health Stroke Scale (NIHSS), and to explore its potential as a predictive marker for clinical outcomes. Methods: We used the data of 1723 AIS patients in the Stroke Center of Quzhou People's Hospital from September 2016 to September 2022 for a cross-sectional study. SII was calculated as platelet count × neutrophil count divided by lymphocyte count. Stroke severity was classified as mild (NIHSS < 8) or severe (NIHSS ≥ 8). Multivariable logistic regression and subgroup analyses were performed to evaluate the relationship between SII levels and NIHSS scores, adjusting for confounders such as age, sex, and comorbidities. Nonlinear associations and threshold effects were further assessed using smooth curve fitting. Results: Elevated SII levels were independently associated with higher stroke severity (OR: 1.04, 95% CI: 1.01-1.07). A nonlinear relationship was identified, with a critical range of SII/100 values (2.4-7.8) demonstrating the strongest correlation with NIHSS scores. Patients in the highest SII quartile (Q4) exhibited a 3.46-fold increase in odds of severe stroke compared to those in the lowest quartile (Q1) ( Conclusion: SII is a robust biomarker for predicting stroke severity in AIS patients. The observed nonlinear relationship highlights its potential utility in identifying critical inflammatory thresholds for risk stratification and personalized therapeutic interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.