ArticleFrontiers in public health2025
The growing impact of human papilloma virus (HPV)-associated cancers in men in Costa Rica: epidemiological and economic burden.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Acceptance and the willingness to pay for human papilloma virus (HPV) vaccine: A systematic review.Human vaccines & immunotherapeutics · 2026Pooled it
- Burden of HPV-associated cancers in Peruvian men: Evidence from national health data.Human vaccines & immunotherapeutics · 2026Article
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7 authors.
Funding
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Abstract
Human papillomavirus (HPV) is the most common sexually transmitted infection in men and women and is responsible for a substantial burden of disease worldwide. Although HPV-related disease burden is high in women due to cervical related disease and cancer, men are directly affected by HPV. According to the World Health Organization (WHO), one in three men has a prevalent HPV infection worldwide. Currently, there is a lack of data regarding the epidemiology and healthcare resource utilization (HCRU) of HPV-associated cancers among Costa Rican men. This study aimed to describe the epidemiological characteristics of HPV-associated male cancer and disease and the HCRU in Costa Rica. HPV-related cancers in men were assessed through retrospective database study for epidemiology and Delphi panel with five experts for HCRU. A total of 1,340 men with penile, anal, and head and neck cancers between 2012 and 2016 were identified in the database, with a mean age of 63.6 years. Anal cancer accounted for 48% of cases, followed by head and neck 44%, and penile cancer 11%. The cumulative rate of HPV-associated cancer in men per 100,000 population increased from 8.6 in 2012 to 55.5 in 2016. According to 4/5 panelists, resources for the disease management were also scarce. Panelists agreed that the cost for HPV management within their institution was 0.6-40,000 USD. Despite the increasing incidence e of HPV-related cancer in men, HPV prevention in men continues to be an under-served issue in public policy that could result in substantial economic and clinical burden. National health authorities should promote strategies to prevent HPV infections and associated diseases among Costa Rican men.
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