ArticleWorld journal of radiology2025
Clinical value and applicability of radiomics in differential diagnosis of dual-phenotype hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
Article in World journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Value of radiomics models in precision diagnosis of dual-phenotype hepatocellular carcinoma and intrahepatic cholangiocarcinoma.World journal of radiology · 2025Article
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7 authors.
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Abstract
backgroundDual-phenotype hepatocellular carcinoma (HCC) is a relatively new subtype of HCC. Studies have shown that in the context of chronic hepatitis, liver cirrhosis, and other liver conditions, some intrahepatic cholangiocarcinomas (ICCs) exhibit an enhancement pattern similar to that of HCC. Both dual-phenotype HCC (DPHCC) and ICC can express biliary markers, making imaging and pathology differentiation difficult. Currently, radiomics is widely used in the differentiation, clinical staging, and prognosis assessment of various diseases. Radiomics can effectively differentiate DPHCC and ICC preoperatively.
aimTo evaluate the value of radiomics in the differential diagnosis of DPHCC and ICC and to validate its clinical applicability.
methodsIn this retrospective study, the data of 53 DPHCC patients and 124 ICC patients were collected retrospectively and randomly divided into training and testing sets at a ratio of 7: 3. After delineation of regions of interest and feature extraction and selection, radiomics models were constructed. Receiver operating characteristic curve analysis was conducted to calculate the area under the curve (AUC) for each model. The AUC values of radiologists with and without assistance from the model were also assessed.
resultsIn the training set, the AUC value of the radiomic model was the highest, and the combined model and the radiomic model had similar AUC (
conclusionRadiomics can differentiate DPHCC and ICC, and with assistance from the developed model, the accuracy of less experienced doctors in the differential diagnosis of these two diseases can be improved.
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