Evidence map›Paper›PMID 40606031›Full record

ArticleDrugs in context2025

Pseudoprogression and improvement of quality of life in a patient with advanced endometrial cancer treated with immunotherapy: a case report.

Valentina Tuninetti, Roberta Danese, Amedeo Calvo, Marco Bellero, Lavinia Bianco, Valentina Ariu, Maria Grazia Ruo Redda, Paola Campisi, Alessandra Bianco, Giovanni De Rosa and 2 more

Abstract readCase Reports
In one paragraph

Article in Drugs in context, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Valentina Tuninetti *Medical Oncology, Ordine Mauriziano Hospital, Turin, Italy.ORCID https://orcid.org/0000-0002-7377-0888
Roberta Danese *Department of Oncology, University of Turin, Turin, Italy.
Amedeo CalvoDepartment of Diagnostic and Interventional Radiology, Ordine Mauriziano Hospital, Turin, Italy.
Marco BelleroDepartment of Hospital Pharmacy, Ordine Mauriziano Hospital, Turin, Italy.
Lavinia BiancoDepartment of Oncology, Radiation Oncology Unit, Ordine Mauriziano Hospital, Turin, Italy.
Valentina AriuMedical Oncology, Ordine Mauriziano Hospital, Turin, Italy.
Maria Grazia Ruo ReddaDepartment of Oncology, Radiation Oncology Unit, Ordine Mauriziano Hospital, Turin, Italy.
Paola CampisiDepartment of Pathology, Ordine Mauriziano Hospital, Turin, Italy.
Alessandra BiancoDepartment of Hospital Pharmacy, Ordine Mauriziano Hospital, Turin, Italy.
Giovanni De RosaDepartment of Pathology, Ordine Mauriziano Hospital, Turin, Italy.
Massimo PetracchiniDepartment of Diagnostic and Interventional Radiology, Ordine Mauriziano Hospital, Turin, Italy.
Giorgio ValabregaMedical Oncology, Ordine Mauriziano Hospital, Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Until recently, treatment options for patients with recurrent or metastatic endometrial cancer (EC) were limited. First-line treatment is usually based on carboplatin and paclitaxel and there was no standard second-line therapy following platinum failure. However, the introduction of immunotherapy has expanded both first-line and later-line options for EC and made determination of mismatch repair status essential. We describe the case of a 56-year-old woman with deficient mismatch repair/microsatellite instability EC who did not respond to first-line treatment with carboplatin and paclitaxel but had a high response to subsequent immunotherapy with dostarlimab. There was initial pseudoprogression of one target lesion but marked improvement in quality of life. This article is part of the

Indexed as

dostarlimabendometrial cancerimmunotherapypseudoprogressionquality of life

Identifiers

PMID40606031
PMCPMC12221137

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.