ArticleDrugs in context2025
Advancing endometrial cancer treatment: exploring immunotherapy and tyrosine kinase inhibitors through clinical cases.
Article in Drugs in context, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Discovery of a Ferroptosis-Related lncRNA-miRNA-mRNA Gene Signature in Endometrial Cancer Through a Comprehensive Co-Expression Network Analysis.Current oncology (Toronto, Ont.) · 2026Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endometrial cancer (EC) is the most common gynaecological malignancy in developed countries, with advanced-stage disease posing significant therapeutic challenges. Standard treatments, including surgery, radiotherapy and chemotherapy, have limited efficacy in recurrent or metastatic cases, necessitating novel therapeutic approaches. Recent molecular classifications of EC have identified subtypes with distinct prognostic and therapeutic implications, particularly those with high immunogenicity. Immunotherapy, specifically immune-checkpoint inhibitors targeting PD-1/PD-L1, has transformed EC treatment. The combination of pembrolizumab, an anti-PD-1 monoclonal antibody, and lenvatinib, a tyrosine kinase inhibitor (TKI), has demonstrated superior efficacy over chemotherapy in the pivotal KEYNOTE-775 trial, significantly improving progression-free and overall survival in advanced EC. Additionally, dostarlimab has shown promise as a monotherapy for mismatch repair-deficient EC, expanding treatment options. This special series in
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