Maltodextrin-modified lipoplexes for enhanced mucosal penetration and efficient mRNA delivery.

Bojan Kopilovic, Nabila Laroui, Mathieu Berchel, Paul-Alain Jaffrès, Patrick Midoux, Mara G Freire, Chantal Pichon

Abstract read

In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bojan KopilovicCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal.

Nabila LarouiCentre de Biophysique Moléculaire (CBM), UPR 4301 CNRS, F-45071, Orléans, France.

Mathieu BerchelUniv Brest, CEMCA, UMR CNRS - UBO 6521, F-29200, Brest, France.

Paul-Alain JaffrèsUniv Brest, CEMCA, UMR CNRS - UBO 6521, F-29200, Brest, France.

Patrick MidouxCentre de Biophysique Moléculaire (CBM), UPR 4301 CNRS, F-45071, Orléans, France.

Mara G FreireCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal.

Chantal PichonCentre de Biophysique Moléculaire (CBM), UPR 4301 CNRS, F-45071, Orléans, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Efficient delivery of messenger ribonucleic acid (mRNA) to mucosal tissues represents a promising approach for localized protein production in the nasal and respiratory tract. Here, we investigate the use of maltodextrin (MDX) as a surface modifier to enhance the delivery of mRNA-loaded histidylated lipoplexes (LXs) to airway epithelial cells. By reducing hydrophobicity, MDX facilitates better penetration through the mucus layer, enabling effective mRNA delivery. MDX-coated LXs improve mRNA delivery and expression

Indexed as

Imidazolium-based lipidsLipoplexesMaltodextrinMucosal penetrationNasal delivery

Identifiers

PMID40605988

DOI10.1016/j.mtbio.2025.101975

PMCPMC12221605

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.