Evidence map›Paper›PMID 40605976›Full record

ArticleGenes & diseases2025

Single-cell landscape of immunological responses in patients with juvenile idiopathic arthritis.

Yun Liu, Xiwen Luo, Liuqing Yang, Qiang Luo, Xiya Luo, Li Xu, Yating Wang, Yunfei An, Yupeng Cun, Xuemei Tang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. CD14Genes & diseases · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yun LiuDepartment of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
Xiwen LuoDepartment of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
Liuqing YangChongqing Key Laboratory of Pediatrics, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
Qiang LuoDepartment of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
Xiya LuoDepartment of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
Li XuDepartment of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
Yating WangDepartment of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
Yunfei AnDepartment of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
Yupeng CunChongqing Key Laboratory of Pediatrics, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
Xuemei TangDepartment of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study aimed to analyze the single-cell transcriptomes of immune cells in juvenile idiopathic arthritis (JIA) patients to understand the cellular heterogeneity within the immune system. Peripheral blood samples from fourteen JIA patients and four healthy individuals were subjected to single-cell RNA sequencing. Various subtypes of JIA were included in the patient cohort. Functional analyses, such as pseudotime trajectories and cell communication studies, were conducted to uncover immune cell changes in JIA patients. Results showed disrupted interferon and acute inflammatory responses in most cell types of JIA patients, with particularly intense responses in systemic JIA (sJIA) patients versus non-sJIA patients. Pseudotime analysis of CD4

Indexed as

Cell-cell communicationImmune cellJuvenile idiopathic arthritisPseudotimetrajectoriesSingle-cell RNA sequencing

Identifiers

PMID40605976
PMCPMC12221592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.