Evidence map›Paper›PMID 40605955›Full record

ArticleUrology case reports2025

Brain metastasis in a patient with metastatic urothelial carcinoma after 7 years of avelumab maintenance therapy: A case report.

Kristoffer Ambeck Aagaard, Halldór Bjarki Einarsson, Sonja Höhle Hjulskov, Maria Teresa Figueroa Simonsen, Andreas Carus

Abstract readCase Reports
In one paragraph

Article in Urology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kristoffer Ambeck AagaardDepartment of Neurosurgery, Aalborg University Hospital, Hobrovej 18-22, 9000, Aalborg, Denmark.
Halldór Bjarki EinarssonDepartment of Neurosurgery, Aalborg University Hospital, Hobrovej 18-22, 9000, Aalborg, Denmark.
Sonja Höhle HjulskovDepartment of Pathology, Aalborg University Hospital, Ladegaardsgade 3, 9000, Aalborg, Denmark.
Maria Teresa Figueroa SimonsenDepartment of Radiology, Aalborg University Hospital, Hobrovej 18-22, 9000, Aalborg, Denmark.
Andreas CarusDepartment of Oncology and Clinical Cancer Research Center, Aalborg University Hospital, Hobrovej 18-22, 9000, Aalborg, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the case of urothelial carcinoma, studies show improved survival in patients with advanced or metastatic disease by the addition of avelumab maintenance therapy after gemcitabine and platinum-based chemotherapy. The recommended follow-up does not include screening for brain metastasis. We describe a case of a male in his sixties who developed a brain metastasis from urothelial carcinoma, after 7 years of avelumab maintenance therapy. As the natural history of the disease changes with modern treatments, we need to monitor the sites of disease progression and be aware in case this traditionally rare site of progression becomes more common.

Indexed as

AvelumabBrain metastasisUrothelial carcinoma

Identifiers

PMID40605955
PMCPMC12214249

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.