ArticleCureus2025
A Rare Case of Hereditary Pancreatitis Unveiling Systemic Lupus Erythematosus in a Young Female Patient.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with varied clinical presentations, sometimes occurring in atypical presentations that cause a delay in diagnosis. Pancreatitis, though uncommon, may be an initial presentation of SLE and needs to be carefully evaluated to rule out other causes. We present the case of a 19-year-old woman who presented with vomiting and abdominal pain and was later diagnosed with hereditary pancreatitis following the detection of a heterozygous SPINK1 gene mutation. Additional evaluation showed systemic manifestations such as non-scarring alopecia, painful oral ulcers, pancytopenia, lupus hepatitis, and a highly positive autoimmune profile, in keeping with a new diagnosis of SLE. This case highlights the diagnostic challenge at the interface of genetic and autoimmune pancreatitis and reinforces the need for a thorough clinical, immunologic, and genetic evaluation in young patients with unexplained abdominal complaints.
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