Evidence map›Paper›PMID 40605857›Full record

ArticleMechanobiology in medicine2025

Causal association analysis between blood metabolomes and osteopenia and therapeutic target prediction for mechanomedicine.

Ruobing Liu, Yaru Huang, Maogang Jiang, Fei Xu, Qilin Pei, Jiajun Ma, Youru Li, Siqi Shen, Bo Zhang, Xiangyang Guo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mechanobiology in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ruobing LiuDepartment of Biomedical Engineering, Fourth Military Medical University, Xi'an, 710032, China.
Yaru HuangDepartment of Health Statistics, School of Preventive Medicine, Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Key Lab of Environmental Health Hazard Assessment and Protection of Shaanxi Province, Key Lab of Free Radical Biology and Medicine of Shaanxi Province, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China.
Maogang JiangDepartment of Medical Engineering, The Second Affiliated Hospital of Air Force Medical University, Xi'an, 710038, China.
Fei XuDepartment of Radiation Oncology, Peking University Third Hospital, Beijing, 100191, China.
Qilin PeiDepartment of Biomedical Engineering, Fourth Military Medical University, Xi'an, 710032, China.
Jiajun MaDepartment of Aerospace Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Youru LiDepartment of Biomedical Engineering, Fourth Military Medical University, Xi'an, 710032, China.
Siqi ShenDepartment of Biomedical Engineering, Fourth Military Medical University, Xi'an, 710032, China.
Bo ZhangDepartment of Biomedical Engineering, Fourth Military Medical University, Xi'an, 710032, China.
Xiangyang GuoDepartment of Biomedical Engineering, Fourth Military Medical University, Xi'an, 710032, China.
Jing CaiDepartment of Biomedical Engineering, Fourth Military Medical University, Xi'an, 710032, China.
Wenwen WangDepartment of Health Statistics, School of Preventive Medicine, Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Key Lab of Environmental Health Hazard Assessment and Protection of Shaanxi Province, Key Lab of Free Radical Biology and Medicine of Shaanxi Province, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blood metabolomes have been linked to osteoporosis, yet the precise causal relationship with osteopenia, its preventable early stage, remains unclear. This study aimed to uncover the genetic causality between blood metabolomes and osteopenia, pinpointing potential targets for mechanomedicine. Utilizing genome-wide association study summary statistics, we analyzed 1091 metabolites and 309 metabolite ratios from 8299 individuals, correlating them with total body bone mineral density (BMD) from 56,284 individuals in the IEU GWAS database and osteopenia data from 408,961 European populations. Through two-sample Mendelian randomization, we investigated the association between blood metabolomes and skeletal characteristics. We then conducted summary-data-based Mendelian randomization (MR) analysis and colocalization analyses to identify causal genes related to skeletal phenotypes, predicting therapeutic targets for osteopenia. Expression of potential targets in osteocytes under fluid shear stress (FSS) stimulation was tested using qRT-PCR to explore mechanical sensitivity and bone health mechanisms. Our findings revealed five metabolites affecting total body BMD and osteopenia, with biliverdin emerging as a potential protective factor against osteopenia (OR ​= ​0.93, 95 ​%CI ​= ​0.88-0.98,

Indexed as

Blood metabolomesBone mineral densityGenome-wide association studyMechanomedicineMendelian randomizationOsteopenia

Identifiers

PMID40605857
PMCPMC12213289

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.