Evidence map›Paper›PMID 40605826›Full record

ArticleNanomedicine (London, England)2025

Transcriptomics insight into occupational exposure to engineered nanoparticles.

Zuzana Simova, Michal Sima, Daniela Pelclova, Pavlina Klusackova, Vladimir Zdimal, Jaroslav Schwarz, Ludmila Maskova, Jiri Klema, Stepanka Dvorackova, Pavel Rossner and 1 more

Abstract read
In one paragraph

Article in Nanomedicine (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zuzana SimovaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Prague, Czech Republic.
Michal SimaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Prague, Czech Republic.
Daniela PelclovaDepartment of Occupational Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic.
Pavlina KlusackovaDepartment of Occupational Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic.
Vladimir ZdimalDepartment of Aerosol Chemistry and Physics, Institute of Chemical Process Fundamentals CAS, Prague, Czech Republic.
Jaroslav SchwarzDepartment of Aerosol Chemistry and Physics, Institute of Chemical Process Fundamentals CAS, Prague, Czech Republic.
Ludmila MaskovaDepartment of Aerosol Chemistry and Physics, Institute of Chemical Process Fundamentals CAS, Prague, Czech Republic.
Jiri KlemaDepartment of Computer Science, Czech Technical University in Prague, Prague, Czech Republic.
Stepanka DvorackovaDepartment of Machining & Assembly, Department of Engineering Technology, Department of Material Science, Faculty of Mechanical Engineering, Technical University in Liberec, Liberec, Czech Republic.
Pavel RossnerDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Prague, Czech Republic.
Andrea RossnerovaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Prague, Czech Republic.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the effect of acute (daily) inhalation of nanoparticles (NPs) on the transcriptomic profile of male nanocomposite research workers with a history of long-term exposure (years). MATERIALS &

methodsWhole genome mRNA and miRNA expression changes were analyzed from blood samples collected before and after machining or welding. Exposure in the work environment was assessed using stationary and personal monitoring.

resultsFollowing PM0.1 exposure, a significant decrease in the expression of

conclusionThe results from this pilot transcriptomic analysis (mRNA and miRNA) indicate that exposure to NPs contributes to immune system deregulation and alters the pathways related to cancer. Therefore, the use of protective equipment, as well as obtaining more data by additional research, is highly recommended.

Indexed as

NanoparticlesOccupational ExposureTranscriptomeAdultGene Expression ProfilingHumansInhalation ExposureMaleMicroRNAsMiddle AgedRNA, MessengerMicroRNAsRNA, MessengermachiningnanoparticlesOccupational exposuretranscriptome changeswelding

Identifiers

PMID40605826
PMCPMC12239771

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.