ArticleMagnetic resonance in medicine2025
Cardiac diffusion kurtosis imaging in the human heart in vivo using 300 mT/m gradients.
Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The Effect of Voxel Volume and Voxel Shape on Cardiac Diffusion Tensor Imaging Metrics.Magnetic resonance in medicine · 2026Article
- Free-Breathing Multi-Slice Co-Registered Cardiac T1, T2, and ADC Mapping With Spin-Echo Echo Planar Imaging.Magnetic resonance in medicine · 2026Article
- Diffusion Tensor MRI of the Heart: The Toolbox Continues to Grow.Circulation. Cardiovascular imaging · 2026Article
- Robust constrained weighted least squares for in vivo human cardiac diffusion kurtosis imaging.Magnetic resonance in medicine · 2026Article
- Motion and Flow Robust Free-Breathing Diffusion Kurtosis Imaging of the Kidney.NMR in biomedicine · 2025Article
- Cardiac diffusion kurtosis imaging in the human heart in vivo using 300 mT/m gradients.Magnetic resonance in medicine · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
purposeDiffusion tensor imaging (DTI) is commonly used in cardiac diffusion magnetic resonance imaging (dMRI). However, the tissue's microstructure (cells, membranes, etc.) restricts the movement of the water molecules, making the spin displacements deviate from Gaussian behavior. This effect may be observed with diffusion kurtosis imaging (DKI) using sufficiently high b-values (
methodsCardiac-gated, second-order motion-compensated dMRI was performed with
resultsWe demonstrate deviation of the signal from monoexponential decay for b-values
conclusionThis work demonstrates the feasibility of quantifying kurtosis effect in the human heart in vivo (at an echo time shorter than typical TEs reported for cardiac DTI), using high-performance gradient systems (which are 4-8 times stronger than on standard clinical scanners). Our work lays the foundation for exploring new biomarkers in cardiac dMRI beyond DTI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.